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Anti-S1PR1/ CD363/ CHEDG1 monoclonal antibody
Anti-S1PR1/ CD363/ CHEDG1 antibody for FACS & in-vivo assay
Go to S1PR1/S1PR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T13852-Ab-1/ GM-Tg-hg-T13852-Ab-2 | Anti-Human S1PR1 monoclonal antibody | Human |
| GM-Tg-rg-T13852-Ab-1/ GM-Tg-rg-T13852-Ab-2 | Anti-Rat S1PR1 monoclonal antibody | Rat |
| GM-Tg-mg-T13852-Ab-1/ GM-Tg-mg-T13852-Ab-2 | Anti-Mouse S1PR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T13852-Ab-1/ GM-Tg-cynog-T13852-Ab-2 | Anti-Cynomolgus/ Rhesus macaque S1PR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T13852-Ab-1/ GM-Tg-felg-T13852-Ab-2 | Anti-Feline S1PR1 monoclonal antibody | Feline |
| GM-Tg-cang-T13852-Ab-1/ GM-Tg-cang-T13852-Ab-2 | Anti-Canine S1PR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T13852-Ab-1/ GM-Tg-bovg-T13852-Ab-2 | Anti-Bovine S1PR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T13852-Ab-1/ GM-Tg-equg-T13852-Ab-2 | Anti-Equine S1PR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T13852-Ab-1/ GM-Tg-hg-T13852-Ab-2; GM-Tg-rg-T13852-Ab-1/ GM-Tg-rg-T13852-Ab-2; GM-Tg-mg-T13852-Ab-1/ GM-Tg-mg-T13852-Ab-2; GM-Tg-cynog-T13852-Ab-1/ GM-Tg-cynog-T13852-Ab-2; GM-Tg-felg-T13852-Ab-1/ GM-Tg-felg-T13852-Ab-2; GM-Tg-cang-T13852-Ab-1/ GM-Tg-cang-T13852-Ab-2; GM-Tg-bovg-T13852-Ab-1/ GM-Tg-bovg-T13852-Ab-2; GM-Tg-equg-T13852-Ab-1/ GM-Tg-equg-T13852-Ab-2 |
| Products Name | Anti-S1PR1 monoclonal antibody |
| Format | mab |
| Target Name | S1PR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-S1PR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S1PR1/ CD363/ CHEDG1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002001 | human S1PR1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002001 | human S1PR1 Lentivirus particle |
| ORF Viral Vector | pGMAAV000276 | Norway rat S1pr1 AAV plasmid |
| ORF Viral Vector | pGMLPm001985 | mouse S1pr1 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000276 | Norway rat S1pr1 AAV particle |
| ORF Viral Vector | vGMLPm001985 | mouse S1pr1 Lentivirus particle |
Target information
| Target ID | GM-T13852 |
| Target Name | S1PR1 |
| Gene ID | 1901,13609,29733,716813,490138,101091218,281135,100050049 |
| Gene Symbol and Synonyms | CD363,CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,Lpb1,S1p,S1P1,S1PR1 |
| Uniprot Accession | P21453,P48303,Q5E9P3 |
| Uniprot Entry Name | S1PR1_HUMAN,S1PR1_RAT,S1PR1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000170989 |
| Target Classification | GPCR |
The target: S1PR1, gene name: S1PR1, also named as CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1. The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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