Anti-EGFR/ EGFR T790M/ ERBB monoclonal antibody

Anti-EGFR/ EGFR T790M/ ERBB antibody for FACS & in-vivo assay

Target products collectionGo to EGFR T790M/EGFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T16538-Ab-1/ GM-Tg-hg-T16538-Ab-2Anti-Human EGFR T790M/EGFR monoclonal antibodyHuman
GM-Tg-rg-T16538-Ab-1/ GM-Tg-rg-T16538-Ab-2Anti-Rat EGFR T790M/EGFR monoclonal antibodyRat
GM-Tg-mg-T16538-Ab-1/ GM-Tg-mg-T16538-Ab-2Anti-Mouse EGFR T790M/EGFR monoclonal antibodyMouse
GM-Tg-cynog-T16538-Ab-1/ GM-Tg-cynog-T16538-Ab-2Anti-Cynomolgus/ Rhesus macaque EGFR T790M/EGFR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T16538-Ab-1/ GM-Tg-felg-T16538-Ab-2Anti-Feline EGFR T790M/EGFR monoclonal antibodyFeline
GM-Tg-cang-T16538-Ab-1/ GM-Tg-cang-T16538-Ab-2Anti-Canine EGFR T790M/EGFR monoclonal antibodyCanine
GM-Tg-bovg-T16538-Ab-1/ GM-Tg-bovg-T16538-Ab-2Anti-Bovine EGFR T790M/EGFR monoclonal antibodyBovine
GM-Tg-equg-T16538-Ab-1/ GM-Tg-equg-T16538-Ab-2Anti-Equine EGFR T790M/EGFR monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T16538-Ab-1/ GM-Tg-hg-T16538-Ab-2; GM-Tg-rg-T16538-Ab-1/ GM-Tg-rg-T16538-Ab-2;
GM-Tg-mg-T16538-Ab-1/ GM-Tg-mg-T16538-Ab-2; GM-Tg-cynog-T16538-Ab-1/ GM-Tg-cynog-T16538-Ab-2;
GM-Tg-felg-T16538-Ab-1/ GM-Tg-felg-T16538-Ab-2; GM-Tg-cang-T16538-Ab-1/ GM-Tg-cang-T16538-Ab-2;
GM-Tg-bovg-T16538-Ab-1/ GM-Tg-bovg-T16538-Ab-2; GM-Tg-equg-T16538-Ab-1/ GM-Tg-equg-T16538-Ab-2
Products NameAnti-EGFR T790M/EGFR monoclonal antibody
Formatmab
Target NameEGFR T790M
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-EGFR T790M benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species EGFR/ EGFR T790M/ ERBB VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000508human EGFR Lentivirus plasmid
    ORF Viral VectorvGMLV000508human EGFR Lentivirus particle
    ORF Viral VectorpGMAD000182human EGFR Adenovirus plasmid
    ORF Viral VectorpGMLV000217human EGFR Lentivirus plasmid
    ORF Viral VectorvGMLV000217human EGFR Lentivirus particle
    ORF Viral VectorvGMLV000216human EGFR Lentivirus particle
    ORF Viral VectorpGMLV000216human EGFR Lentivirus plasmid
    ORF Viral VectorvGMAD000182human EGFR Adenovirus particle


    Target information

    Target IDGM-T16538
    Target NameEGFR T790M
    Gene ID1956,13649,24329,613027,404306,100510799,407217,100067755
    Gene Symbol and Synonyms9030024J15Rik,EGFR,ERBB,ErbB-1,ERBB1,Errb1,ERRP,HER1,mENA,NISBD2,PIG61,wa-2,wa2,Wa5
    Uniprot AccessionP00533,P55245
    Uniprot Entry NameEGFR_HUMAN,EGFR_MACMU
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseBreast Cancer, Non-Small Cell Lung Cancer, gastric cancer, apoptosis, Asphyxia neonatorum, Urinary bladder urothelial carcinoma
    Gene EnsemblENSG00000146648
    Target ClassificationKinase

    The target: EGFR T790M, gene name: EGFR, also named as ERBB, ERBB1, HER1, NISBD2, PIG61, mENA. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.