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Anti-ATG7/ APG7-LIKE/ APG7L functional antibody
Anti-ATG7/ APG7-LIKE/ APG7L functional antibody for cell culture, ELISA & in-vivo assay
Go to ATG7/ATG7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T20302-Ab-1/ GM-Tg-hg-T20302-Ab-2 | Anti-Human ATG7 monoclonal antibody | Human |
| GM-Tg-rg-T20302-Ab-1/ GM-Tg-rg-T20302-Ab-2 | Anti-Rat ATG7 monoclonal antibody | Rat |
| GM-Tg-mg-T20302-Ab-1/ GM-Tg-mg-T20302-Ab-2 | Anti-Mouse ATG7 monoclonal antibody | Mouse |
| GM-Tg-cynog-T20302-Ab-1/ GM-Tg-cynog-T20302-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ATG7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T20302-Ab-1/ GM-Tg-felg-T20302-Ab-2 | Anti-Feline ATG7 monoclonal antibody | Feline |
| GM-Tg-cang-T20302-Ab-1/ GM-Tg-cang-T20302-Ab-2 | Anti-Canine ATG7 monoclonal antibody | Canine |
| GM-Tg-bovg-T20302-Ab-1/ GM-Tg-bovg-T20302-Ab-2 | Anti-Bovine ATG7 monoclonal antibody | Bovine |
| GM-Tg-equg-T20302-Ab-1/ GM-Tg-equg-T20302-Ab-2 | Anti-Equine ATG7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T20302-Ab-1/ GM-Tg-hg-T20302-Ab-2; GM-Tg-rg-T20302-Ab-1/ GM-Tg-rg-T20302-Ab-2; GM-Tg-mg-T20302-Ab-1/ GM-Tg-mg-T20302-Ab-2; GM-Tg-cynog-T20302-Ab-1/ GM-Tg-cynog-T20302-Ab-2; GM-Tg-felg-T20302-Ab-1/ GM-Tg-felg-T20302-Ab-2; GM-Tg-cang-T20302-Ab-1/ GM-Tg-cang-T20302-Ab-2; GM-Tg-bovg-T20302-Ab-1/ GM-Tg-bovg-T20302-Ab-2; GM-Tg-equg-T20302-Ab-1/ GM-Tg-equg-T20302-Ab-2 |
| Products Name | Anti-ATG7 monoclonal antibody |
| Format | mab |
| Target Name | ATG7 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ATG7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T20302-Ag-1 | Recombinant multi-species ATG7/ APG7-LIKE/ APG7L protein |
| ORF Viral Vector | pGMAD000194 | human ATG7 Adenovirus plasmid |
| ORF Viral Vector | vGMLV000516 | human ATG7 Lentivirus particle |
| ORF Viral Vector | pGMLV000190 | human ATG7 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000516 | human ATG7 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000190 | human ATG7 Lentivirus particle |
| ORF Viral Vector | vGMAD000194 | human ATG7 Adenovirus particle |
| ORF Viral Vector | pGMAD000030 | rat Atg7 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000420 | Norway rat Atg7 Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000084 | mouse Atg7 AAV plasmid |
| ORF Viral Vector | vGMAD000030 | rat Atg7 Adenovirus particle |
| ORF Viral Vector | vGMAD000420 | Norway rat Atg7 Adenovirus particle |
| ORF Viral Vector | vGMAAV000084 | mouse Atg7 AAV particle |
Target information
| Target ID | GM-T20302 |
| Target Name | ATG7 |
| Gene ID | 10533,74244,312647,696238,476533,101093088,787967,100051544 |
| Gene Symbol and Synonyms | 1810013K23Rik,Agp7,APG7-LIKE,APG7L,ATG7,Atg7l,Gm21553,GSA7,SCAR31 |
| Uniprot Accession | O95352,Q641Y5 |
| Uniprot Entry Name | ATG7_HUMAN,ATG7_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000197548 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ATG7, gene name: ATG7, also named as APG7-LIKE, APG7L, GSA7. This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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