Anti-CSF1R/ C-FMS/ CD115 monoclonal antibody

Anti-CSF1R/ C-FMS/ CD115 antibody for FACS & in-vivo assay

Target products collectionGo to CSF1R/CSF1R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T20333-Ab-1/ GM-Tg-hg-T20333-Ab-2Anti-Human CSF1R monoclonal antibodyHuman
GM-Tg-rg-T20333-Ab-1/ GM-Tg-rg-T20333-Ab-2Anti-Rat CSF1R monoclonal antibodyRat
GM-Tg-mg-T20333-Ab-1/ GM-Tg-mg-T20333-Ab-2Anti-Mouse CSF1R monoclonal antibodyMouse
GM-Tg-cynog-T20333-Ab-1/ GM-Tg-cynog-T20333-Ab-2Anti-Cynomolgus/ Rhesus macaque CSF1R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T20333-Ab-1/ GM-Tg-felg-T20333-Ab-2Anti-Feline CSF1R monoclonal antibodyFeline
GM-Tg-cang-T20333-Ab-1/ GM-Tg-cang-T20333-Ab-2Anti-Canine CSF1R monoclonal antibodyCanine
GM-Tg-bovg-T20333-Ab-1/ GM-Tg-bovg-T20333-Ab-2Anti-Bovine CSF1R monoclonal antibodyBovine
GM-Tg-equg-T20333-Ab-1/ GM-Tg-equg-T20333-Ab-2Anti-Equine CSF1R monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T20333-Ab-1/ GM-Tg-hg-T20333-Ab-2; GM-Tg-rg-T20333-Ab-1/ GM-Tg-rg-T20333-Ab-2;
GM-Tg-mg-T20333-Ab-1/ GM-Tg-mg-T20333-Ab-2; GM-Tg-cynog-T20333-Ab-1/ GM-Tg-cynog-T20333-Ab-2;
GM-Tg-felg-T20333-Ab-1/ GM-Tg-felg-T20333-Ab-2; GM-Tg-cang-T20333-Ab-1/ GM-Tg-cang-T20333-Ab-2;
GM-Tg-bovg-T20333-Ab-1/ GM-Tg-bovg-T20333-Ab-2; GM-Tg-equg-T20333-Ab-1/ GM-Tg-equg-T20333-Ab-2
Products NameAnti-CSF1R monoclonal antibody
Formatmab
Target NameCSF1R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CSF1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-174Pre-Made Emactuzumab biosimilar, Whole mAb, Anti-CSF1R Antibody: Anti-FMS/CSFR/FIM2/HDLS/C-FMS/CD115/HDLS1/CSF-1R/BANDDOS/M-CSF-R therapeutic antibody
    BiosimilarGMP-Bios-ab-042Pre-Made Axatilimab biosimilar, Whole mAb, Anti-CSF1R Antibody: Anti-FMS/CSFR/FIM2/HDLS/C-FMS/CD115/HDLS1/CSF-1R/BANDDOS/M-CSF-R therapeutic antibody
    BiosimilarGMP-Bios-ab-087Pre-Made Cabiralizumab biosimilar, Whole mAb, Anti-CSF1R Antibody: Anti-FMS/CSFR/FIM2/HDLS/C-FMS/CD115/HDLS1/CSF-1R/BANDDOS/M-CSF-R therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CSF1R/ C-FMS/ CD115 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T20333
    Target NameCSF1R
    Gene ID1436,12978,307403,711512,489188,493706,509418,100060422
    Gene Symbol and SynonymsBANDDOS,C-FMS,CD115,CSF-1-R,CSF-1R,CSF1,CSF1R,Csfmr,CSFR,Fim-2,FIM2,FMS,GPSC,HDLS,HDLS1,M-CSF,M-CSF-R,M-CSFR,mrfms
    Uniprot AccessionP07333,Q00495,P13369
    Uniprot Entry NameCSF1R_HUMAN,CSF1R_RAT,CSF1R_FELCA
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000182578
    Target ClassificationCheckpoint-Immuno Oncology, Kinase, Tumor-associated antigen (TAA)

    The target: CSF1R, gene name: CSF1R, also named as C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R. The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.