Anti-SC6A2/ NET/ SLC6A2 monoclonal antibody

Anti-SC6A2/ NET/ SLC6A2 antibody for FACS & in-vivo assay

Target products collectionGo to NET/SLC6A2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T21945-Ab-1/ GM-Tg-hg-T21945-Ab-2Anti-Human NET/SLC6A2 monoclonal antibodyHuman
GM-Tg-rg-T21945-Ab-1/ GM-Tg-rg-T21945-Ab-2Anti-Rat NET/SLC6A2 monoclonal antibodyRat
GM-Tg-mg-T21945-Ab-1/ GM-Tg-mg-T21945-Ab-2Anti-Mouse NET/SLC6A2 monoclonal antibodyMouse
GM-Tg-cynog-T21945-Ab-1/ GM-Tg-cynog-T21945-Ab-2Anti-Cynomolgus/ Rhesus macaque NET/SLC6A2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T21945-Ab-1/ GM-Tg-felg-T21945-Ab-2Anti-Feline NET/SLC6A2 monoclonal antibodyFeline
GM-Tg-cang-T21945-Ab-1/ GM-Tg-cang-T21945-Ab-2Anti-Canine NET/SLC6A2 monoclonal antibodyCanine
GM-Tg-bovg-T21945-Ab-1/ GM-Tg-bovg-T21945-Ab-2Anti-Bovine NET/SLC6A2 monoclonal antibodyBovine
GM-Tg-equg-T21945-Ab-1/ GM-Tg-equg-T21945-Ab-2Anti-Equine NET/SLC6A2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T21945-Ab-1/ GM-Tg-hg-T21945-Ab-2; GM-Tg-rg-T21945-Ab-1/ GM-Tg-rg-T21945-Ab-2;
GM-Tg-mg-T21945-Ab-1/ GM-Tg-mg-T21945-Ab-2; GM-Tg-cynog-T21945-Ab-1/ GM-Tg-cynog-T21945-Ab-2;
GM-Tg-felg-T21945-Ab-1/ GM-Tg-felg-T21945-Ab-2; GM-Tg-cang-T21945-Ab-1/ GM-Tg-cang-T21945-Ab-2;
GM-Tg-bovg-T21945-Ab-1/ GM-Tg-bovg-T21945-Ab-2; GM-Tg-equg-T21945-Ab-1/ GM-Tg-equg-T21945-Ab-2
Products NameAnti-NET/SLC6A2 monoclonal antibody
Formatmab
Target NameNET
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NET benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SC6A2/ NET/ SLC6A2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm005238mouse Slc6a2 Lentivirus plasmid
    ORF Viral VectorvGMLPm005238mouse Slc6a2 Lentivirus particle


    Target information

    Target IDGM-T21945
    Target NameNET
    Gene ID6530,20538,83511,613238,487272,101099605,282363,100061346
    Gene Symbol and SynonymsNAT,NAT-1,NAT1,NE-T,NET,NET1,SLC6A2,SLC6A5
    Uniprot AccessionP23975,O62696,P51143
    Uniprot Entry NameSC6A2_HUMAN,ARY1_FELCA,SC6A2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000103546
    Target ClassificationN/A

    The target: NET, gene name: SLC6A2, also named as NAT1, NET, NET1, SLC6A5. This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.