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Anti-DRD1/ D1R/ DADRA monoclonal antibody
Anti-DRD1/ D1R/ DADRA antibody for FACS & in-vivo assay
Go to D1R/DRD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T22118-Ab-1/ GM-Tg-hg-T22118-Ab-2 | Anti-Human D1R/DRD1 monoclonal antibody | Human |
| GM-Tg-rg-T22118-Ab-1/ GM-Tg-rg-T22118-Ab-2 | Anti-Rat D1R/DRD1 monoclonal antibody | Rat |
| GM-Tg-mg-T22118-Ab-1/ GM-Tg-mg-T22118-Ab-2 | Anti-Mouse D1R/DRD1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T22118-Ab-1/ GM-Tg-cynog-T22118-Ab-2 | Anti-Cynomolgus/ Rhesus macaque D1R/DRD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T22118-Ab-1/ GM-Tg-felg-T22118-Ab-2 | Anti-Feline D1R/DRD1 monoclonal antibody | Feline |
| GM-Tg-cang-T22118-Ab-1/ GM-Tg-cang-T22118-Ab-2 | Anti-Canine D1R/DRD1 monoclonal antibody | Canine |
| GM-Tg-bovg-T22118-Ab-1/ GM-Tg-bovg-T22118-Ab-2 | Anti-Bovine D1R/DRD1 monoclonal antibody | Bovine |
| GM-Tg-equg-T22118-Ab-1/ GM-Tg-equg-T22118-Ab-2 | Anti-Equine D1R/DRD1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T22118-Ab-1/ GM-Tg-hg-T22118-Ab-2; GM-Tg-rg-T22118-Ab-1/ GM-Tg-rg-T22118-Ab-2; GM-Tg-mg-T22118-Ab-1/ GM-Tg-mg-T22118-Ab-2; GM-Tg-cynog-T22118-Ab-1/ GM-Tg-cynog-T22118-Ab-2; GM-Tg-felg-T22118-Ab-1/ GM-Tg-felg-T22118-Ab-2; GM-Tg-cang-T22118-Ab-1/ GM-Tg-cang-T22118-Ab-2; GM-Tg-bovg-T22118-Ab-1/ GM-Tg-bovg-T22118-Ab-2; GM-Tg-equg-T22118-Ab-1/ GM-Tg-equg-T22118-Ab-2 |
| Products Name | Anti-D1R/DRD1 monoclonal antibody |
| Format | mab |
| Target Name | D1R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-D1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DRD1/ D1R/ DADRA VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm002657 | mouse Drd1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002657 | mouse Drd1 Lentivirus particle |
Target information
| Target ID | GM-T22118 |
| Target Name | D1R |
| Gene ID | 1812,13488,24316,697796,489110,101085098,281125,100058846 |
| Gene Symbol and Synonyms | C030036C15Rik,D1a,DADR,Drd-1,DRD1,DRD1A,Gpcr15 |
| Uniprot Accession | P21728,P18901,O77680,Q95136 |
| Uniprot Entry Name | DRD1_HUMAN,DRD1_MACMU,DRD1_RAT,DRD1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000184845 |
| Target Classification | GPCR |
The target: D1R, gene name: DRD1, also named as DADRA, DRD1. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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