Anti-GBRA5/ GABRA5 monoclonal antibody

Anti-GBRA5/ GABRA5 antibody for FACS & in-vivo assay

Target products collectionGo to GABRA5/GABRA5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T26368-Ab-1/ GM-Tg-hg-T26368-Ab-2Anti-Human GABRA5 monoclonal antibodyHuman
GM-Tg-rg-T26368-Ab-1/ GM-Tg-rg-T26368-Ab-2Anti-Rat GABRA5 monoclonal antibodyRat
GM-Tg-mg-T26368-Ab-1/ GM-Tg-mg-T26368-Ab-2Anti-Mouse GABRA5 monoclonal antibodyMouse
GM-Tg-cynog-T26368-Ab-1/ GM-Tg-cynog-T26368-Ab-2Anti-Cynomolgus/ Rhesus macaque GABRA5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T26368-Ab-1/ GM-Tg-felg-T26368-Ab-2Anti-Feline GABRA5 monoclonal antibodyFeline
GM-Tg-cang-T26368-Ab-1/ GM-Tg-cang-T26368-Ab-2Anti-Canine GABRA5 monoclonal antibodyCanine
GM-Tg-bovg-T26368-Ab-1/ GM-Tg-bovg-T26368-Ab-2Anti-Bovine GABRA5 monoclonal antibodyBovine
GM-Tg-equg-T26368-Ab-1/ GM-Tg-equg-T26368-Ab-2Anti-Equine GABRA5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T26368-Ab-1/ GM-Tg-hg-T26368-Ab-2; GM-Tg-rg-T26368-Ab-1/ GM-Tg-rg-T26368-Ab-2;
GM-Tg-mg-T26368-Ab-1/ GM-Tg-mg-T26368-Ab-2; GM-Tg-cynog-T26368-Ab-1/ GM-Tg-cynog-T26368-Ab-2;
GM-Tg-felg-T26368-Ab-1/ GM-Tg-felg-T26368-Ab-2; GM-Tg-cang-T26368-Ab-1/ GM-Tg-cang-T26368-Ab-2;
GM-Tg-bovg-T26368-Ab-1/ GM-Tg-bovg-T26368-Ab-2; GM-Tg-equg-T26368-Ab-1/ GM-Tg-equg-T26368-Ab-2
Products NameAnti-GABRA5 monoclonal antibody
Formatmab
Target NameGABRA5
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GABRA5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GBRA5/ GABRA5 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T26368
    Target NameGABRA5
    Gene ID2558,110886,29707,711838,488688,101090773,523515,100050880
    Gene Symbol and SynonymsA230018I05Rik,DEE79,EIEE79,GABRA5
    Uniprot AccessionP31644,P19969,Q08E50
    Uniprot Entry NameGBRA5_HUMAN,GBRA5_RAT,GBRA5_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000186297
    Target ClassificationIon Channel

    The target: GABRA5, gene name: GABRA5, also named as . GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.