Anti-TK1 monoclonal antibody

Pre-made anti-TK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to TK1/TK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T30081-Ab-1/ GM-Tg-hg-T30081-Ab-2Anti-Human TK1 monoclonal antibodyHuman
GM-Tg-rg-T30081-Ab-1/ GM-Tg-rg-T30081-Ab-2Anti-Rat TK1 monoclonal antibodyRat
GM-Tg-mg-T30081-Ab-1/ GM-Tg-mg-T30081-Ab-2Anti-Mouse TK1 monoclonal antibodyMouse
GM-Tg-cynog-T30081-Ab-1/ GM-Tg-cynog-T30081-Ab-2Anti-Cynomolgus/ Rhesus macaque TK1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T30081-Ab-1/ GM-Tg-felg-T30081-Ab-2Anti-Feline TK1 monoclonal antibodyFeline
GM-Tg-cang-T30081-Ab-1/ GM-Tg-cang-T30081-Ab-2Anti-Canine TK1 monoclonal antibodyCanine
GM-Tg-bovg-T30081-Ab-1/ GM-Tg-bovg-T30081-Ab-2Anti-Bovine TK1 monoclonal antibodyBovine
GM-Tg-equg-T30081-Ab-1/ GM-Tg-equg-T30081-Ab-2Anti-Equine TK1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T30081-Ab-1/ GM-Tg-hg-T30081-Ab-2; GM-Tg-rg-T30081-Ab-1/ GM-Tg-rg-T30081-Ab-2;
GM-Tg-mg-T30081-Ab-1/ GM-Tg-mg-T30081-Ab-2; GM-Tg-cynog-T30081-Ab-1/ GM-Tg-cynog-T30081-Ab-2;
GM-Tg-felg-T30081-Ab-1/ GM-Tg-felg-T30081-Ab-2; GM-Tg-cang-T30081-Ab-1/ GM-Tg-cang-T30081-Ab-2;
GM-Tg-bovg-T30081-Ab-1/ GM-Tg-bovg-T30081-Ab-2; GM-Tg-equg-T30081-Ab-1/ GM-Tg-equg-T30081-Ab-2
Products NameAnti-TK1 monoclonal antibody
Formatmab
Target NameTK1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-TK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T30081-Ag-1Recombinant multi-species KITH/ TK1/ TK2 protein
    ORF Viral VectorpGMLPm000573mouse Tk1 Lentivirus plasmid
    ORF Viral VectorvGMLPm000573mouse Tk1 Lentivirus particle


    Target information

    Target IDGM-T30081
    Target NameTK1
    Gene ID7083,21877,24834,709403,100855947,101101270,504652,100057908
    Gene Symbol and SynonymsD530002A18Rik,Tk,Tk-1,TK1,Tk1a,Tk1b,TK2
    Uniprot AccessionP04183,P27158,A5D7R8
    Uniprot Entry NameKITH_HUMAN,KITH_RAT,KITH_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target, Diagnostics Biomarker, Immuno-oncology Target
    DiseaseN/A
    Gene EnsemblENSG00000167900
    Target ClassificationCheckpoint-Immuno Oncology

    The target: TK1, gene name: TK1, also named as TK2. The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates d™P and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.