Anti-CAC1A/ CACNA1A/ APCA monoclonal antibody

Anti-CAC1A/ CACNA1A/ APCA antibody for FACS & in-vivo assay

Target products collectionGo to CACNA1A/CACNA1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T34949-Ab-1/ GM-Tg-hg-T34949-Ab-2Anti-Human CACNA1A monoclonal antibodyHuman
GM-Tg-rg-T34949-Ab-1/ GM-Tg-rg-T34949-Ab-2Anti-Rat CACNA1A monoclonal antibodyRat
GM-Tg-mg-T34949-Ab-1/ GM-Tg-mg-T34949-Ab-2Anti-Mouse CACNA1A monoclonal antibodyMouse
GM-Tg-cynog-T34949-Ab-1/ GM-Tg-cynog-T34949-Ab-2Anti-Cynomolgus/ Rhesus macaque CACNA1A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T34949-Ab-1/ GM-Tg-felg-T34949-Ab-2Anti-Feline CACNA1A monoclonal antibodyFeline
GM-Tg-cang-T34949-Ab-1/ GM-Tg-cang-T34949-Ab-2Anti-Canine CACNA1A monoclonal antibodyCanine
GM-Tg-bovg-T34949-Ab-1/ GM-Tg-bovg-T34949-Ab-2Anti-Bovine CACNA1A monoclonal antibodyBovine
GM-Tg-equg-T34949-Ab-1/ GM-Tg-equg-T34949-Ab-2Anti-Equine CACNA1A monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T34949-Ab-1/ GM-Tg-hg-T34949-Ab-2; GM-Tg-rg-T34949-Ab-1/ GM-Tg-rg-T34949-Ab-2;
GM-Tg-mg-T34949-Ab-1/ GM-Tg-mg-T34949-Ab-2; GM-Tg-cynog-T34949-Ab-1/ GM-Tg-cynog-T34949-Ab-2;
GM-Tg-felg-T34949-Ab-1/ GM-Tg-felg-T34949-Ab-2; GM-Tg-cang-T34949-Ab-1/ GM-Tg-cang-T34949-Ab-2;
GM-Tg-bovg-T34949-Ab-1/ GM-Tg-bovg-T34949-Ab-2; GM-Tg-equg-T34949-Ab-1/ GM-Tg-equg-T34949-Ab-2
Products NameAnti-CACNA1A monoclonal antibody
Formatmab
Target NameCACNA1A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CACNA1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CAC1A/ CACNA1A/ APCA VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T34949
    Target NameCACNA1A
    Gene ID773,12286,25398,718291,100686650,101094827,282648,100063873
    Gene Symbol and Synonymsalpha1A,APCA,BccA1,BI,Caca1a,CACNA1A,CACNL1A4,CAV2.1,Ccha1a,DEE42,EA2,EIEE42,FHM,HPCA,la,MHP,MHP1,nmf352,rbA-1,rkr,SCA6,smrl,tg
    Uniprot AccessionO00555,P54282
    Uniprot Entry NameCAC1A_HUMAN,CAC1A_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000141837
    Target ClassificationN/A

    The target: CACNA1A, gene name: CACNA1A, also named as APCA, BI, CACNL1A4, CAV2.1, EA2, EIEE42, FHM, HPCA, MHP, MHP1, SCA6. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.