Anti-IMPDH1 monoclonal antibody
Pre-made anti-IMPDH1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T40111-Ab-1/ GM-Tg-hg-T40111-Ab-2 | Anti-Human IMPDH1 monoclonal antibody | Human |
GM-Tg-rg-T40111-Ab-1/ GM-Tg-rg-T40111-Ab-2 | Anti-Rat IMPDH1 monoclonal antibody | Rat |
GM-Tg-mg-T40111-Ab-1/ GM-Tg-mg-T40111-Ab-2 | Anti-Mouse IMPDH1 monoclonal antibody | Mouse |
GM-Tg-cynog-T40111-Ab-1/ GM-Tg-cynog-T40111-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IMPDH1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T40111-Ab-1/ GM-Tg-felg-T40111-Ab-2 | Anti-Feline IMPDH1 monoclonal antibody | Feline |
GM-Tg-cang-T40111-Ab-1/ GM-Tg-cang-T40111-Ab-2 | Anti-Canine IMPDH1 monoclonal antibody | Canine |
GM-Tg-bovg-T40111-Ab-1/ GM-Tg-bovg-T40111-Ab-2 | Anti-Bovine IMPDH1 monoclonal antibody | Bovine |
GM-Tg-equg-T40111-Ab-1/ GM-Tg-equg-T40111-Ab-2 | Anti-Equine IMPDH1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T40111-Ab-1/ GM-Tg-hg-T40111-Ab-2; GM-Tg-rg-T40111-Ab-1/ GM-Tg-rg-T40111-Ab-2; GM-Tg-mg-T40111-Ab-1/ GM-Tg-mg-T40111-Ab-2; GM-Tg-cynog-T40111-Ab-1/ GM-Tg-cynog-T40111-Ab-2; GM-Tg-felg-T40111-Ab-1/ GM-Tg-felg-T40111-Ab-2; GM-Tg-cang-T40111-Ab-1/ GM-Tg-cang-T40111-Ab-2; GM-Tg-bovg-T40111-Ab-1/ GM-Tg-bovg-T40111-Ab-2; GM-Tg-equg-T40111-Ab-1/ GM-Tg-equg-T40111-Ab-2 |
Products Name | Anti-IMPDH1 monoclonal antibody |
Format | mab |
Target Name | IMPDH1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-IMPDH1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T40111-Ag-1 | Recombinant multi-species IMDH1/ IMPDH1/ IMPD protein |
ORF Viral Vector | pGMLPm002048 | mouse Impdh1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm002048 | mouse Impdh1 Lentivirus particle |
Target information
Target ID | GM-T40111 |
Target Name | IMPDH1 |
Gene ID | 3614,23917,362329,701039,100856092,101084274,504305,100071737 |
Gene Symbol and Synonyms | B930086D20Rik,IMPD,IMPD 1,IMPD1,IMPDH 1,IMPDH-I,IMPDH1,LCA11,RP10,sWSS2608 |
Uniprot Accession | P20839,D3ZLZ7,A0JNA3 |
Uniprot Entry Name | IMDH1_HUMAN,IMDH1_RAT,IMDH1_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000106348 |
Target Classification | N/A |
The target: IMPDH1, gene name: IMPDH1, also named as IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608. The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.