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Anti-AT1A1/ ATP1A1/ CMT2DD monoclonal antibody
Anti-AT1A1/ ATP1A1/ CMT2DD antibody for FACS & in-vivo assay
Go to ATP1A1/ATP1A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T40800-Ab-1/ GM-Tg-hg-T40800-Ab-2 | Anti-Human ATP1A1 monoclonal antibody | Human |
| GM-Tg-rg-T40800-Ab-1/ GM-Tg-rg-T40800-Ab-2 | Anti-Rat ATP1A1 monoclonal antibody | Rat |
| GM-Tg-mg-T40800-Ab-1/ GM-Tg-mg-T40800-Ab-2 | Anti-Mouse ATP1A1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T40800-Ab-1/ GM-Tg-cynog-T40800-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ATP1A1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T40800-Ab-1/ GM-Tg-felg-T40800-Ab-2 | Anti-Feline ATP1A1 monoclonal antibody | Feline |
| GM-Tg-cang-T40800-Ab-1/ GM-Tg-cang-T40800-Ab-2 | Anti-Canine ATP1A1 monoclonal antibody | Canine |
| GM-Tg-bovg-T40800-Ab-1/ GM-Tg-bovg-T40800-Ab-2 | Anti-Bovine ATP1A1 monoclonal antibody | Bovine |
| GM-Tg-equg-T40800-Ab-1/ GM-Tg-equg-T40800-Ab-2 | Anti-Equine ATP1A1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T40800-Ab-1/ GM-Tg-hg-T40800-Ab-2; GM-Tg-rg-T40800-Ab-1/ GM-Tg-rg-T40800-Ab-2; GM-Tg-mg-T40800-Ab-1/ GM-Tg-mg-T40800-Ab-2; GM-Tg-cynog-T40800-Ab-1/ GM-Tg-cynog-T40800-Ab-2; GM-Tg-felg-T40800-Ab-1/ GM-Tg-felg-T40800-Ab-2; GM-Tg-cang-T40800-Ab-1/ GM-Tg-cang-T40800-Ab-2; GM-Tg-bovg-T40800-Ab-1/ GM-Tg-bovg-T40800-Ab-2; GM-Tg-equg-T40800-Ab-1/ GM-Tg-equg-T40800-Ab-2 |
| Products Name | Anti-ATP1A1 monoclonal antibody |
| Format | mab |
| Target Name | ATP1A1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ATP1A1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AT1A1/ ATP1A1/ CMT2DD VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001453 | human ATP1A1 Lentivirus particle |
| ORF Viral Vector | pGMLP001453 | human ATP1A1 Lentivirus plasmid |
Target information
| Target ID | GM-T40800 |
| Target Name | ATP1A1 |
| Gene ID | 476,11928,24211,710368,403992,101083695,282144,100034139 |
| Gene Symbol and Synonyms | ATP1A1,Atpa-1,CMT2DD,HOMGSMR2,Nkaa1b |
| Uniprot Accession | P05023,P06685,P50997,Q08DA1,P18907 |
| Uniprot Entry Name | AT1A1_HUMAN,AT1A1_RAT,AT1A1_CANLF,AT1A1_BOVIN,AT1A1_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000163399 |
| Target Classification | N/A |
The target: ATP1A1, gene name: ATP1A1, also named as CMT2DD. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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