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Anti-ACM2/ CHRM2/ HM2 monoclonal antibody
Anti-ACM2/ CHRM2/ HM2 antibody for FACS & in-vivo assay
Go to CHRM2/CHRM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T46185-Ab-1/ GM-Tg-hg-T46185-Ab-2 | Anti-Human CHRM2 monoclonal antibody | Human |
| GM-Tg-rg-T46185-Ab-1/ GM-Tg-rg-T46185-Ab-2 | Anti-Rat CHRM2 monoclonal antibody | Rat |
| GM-Tg-mg-T46185-Ab-1/ GM-Tg-mg-T46185-Ab-2 | Anti-Mouse CHRM2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T46185-Ab-1/ GM-Tg-cynog-T46185-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRM2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T46185-Ab-1/ GM-Tg-felg-T46185-Ab-2 | Anti-Feline CHRM2 monoclonal antibody | Feline |
| GM-Tg-cang-T46185-Ab-1/ GM-Tg-cang-T46185-Ab-2 | Anti-Canine CHRM2 monoclonal antibody | Canine |
| GM-Tg-bovg-T46185-Ab-1/ GM-Tg-bovg-T46185-Ab-2 | Anti-Bovine CHRM2 monoclonal antibody | Bovine |
| GM-Tg-equg-T46185-Ab-1/ GM-Tg-equg-T46185-Ab-2 | Anti-Equine CHRM2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T46185-Ab-1/ GM-Tg-hg-T46185-Ab-2; GM-Tg-rg-T46185-Ab-1/ GM-Tg-rg-T46185-Ab-2; GM-Tg-mg-T46185-Ab-1/ GM-Tg-mg-T46185-Ab-2; GM-Tg-cynog-T46185-Ab-1/ GM-Tg-cynog-T46185-Ab-2; GM-Tg-felg-T46185-Ab-1/ GM-Tg-felg-T46185-Ab-2; GM-Tg-cang-T46185-Ab-1/ GM-Tg-cang-T46185-Ab-2; GM-Tg-bovg-T46185-Ab-1/ GM-Tg-bovg-T46185-Ab-2; GM-Tg-equg-T46185-Ab-1/ GM-Tg-equg-T46185-Ab-2 |
| Products Name | Anti-CHRM2 monoclonal antibody |
| Format | mab |
| Target Name | CHRM2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRM2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACM2/ CHRM2/ HM2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001379 | human CHRM2 Lentivirus particle |
| ORF Viral Vector | pGMLP001379 | human CHRM2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003856 | mouse Chrm2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003856 | mouse Chrm2 Lentivirus particle |
Target information
| Target ID | GM-T46185 |
| Target Name | CHRM2 |
| Gene ID | 1129,243764,81645,714780,403858,101099790,522170,100064906 |
| Gene Symbol and Synonyms | AChR-M2,Acm2,Chrm-2,CHRM2,HM2,M2 |
| Uniprot Accession | P08172,P10980,P41985 |
| Uniprot Entry Name | ACM2_HUMAN,ACM2_RAT,ACM2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000181072 |
| Target Classification | N/A |
The target: CHRM2, gene name: CHRM2, also named as HM2. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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