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Anti-RXRG monoclonal antibody
Pre-made anti-RXRG monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RXRG/RXRG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T46456-Ab-1/ GM-Tg-hg-T46456-Ab-2 | Anti-Human RXRG monoclonal antibody | Human |
| GM-Tg-rg-T46456-Ab-1/ GM-Tg-rg-T46456-Ab-2 | Anti-Rat RXRG monoclonal antibody | Rat |
| GM-Tg-mg-T46456-Ab-1/ GM-Tg-mg-T46456-Ab-2 | Anti-Mouse RXRG monoclonal antibody | Mouse |
| GM-Tg-cynog-T46456-Ab-1/ GM-Tg-cynog-T46456-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RXRG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T46456-Ab-1/ GM-Tg-felg-T46456-Ab-2 | Anti-Feline RXRG monoclonal antibody | Feline |
| GM-Tg-cang-T46456-Ab-1/ GM-Tg-cang-T46456-Ab-2 | Anti-Canine RXRG monoclonal antibody | Canine |
| GM-Tg-bovg-T46456-Ab-1/ GM-Tg-bovg-T46456-Ab-2 | Anti-Bovine RXRG monoclonal antibody | Bovine |
| GM-Tg-equg-T46456-Ab-1/ GM-Tg-equg-T46456-Ab-2 | Anti-Equine RXRG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T46456-Ab-1/ GM-Tg-hg-T46456-Ab-2; GM-Tg-rg-T46456-Ab-1/ GM-Tg-rg-T46456-Ab-2; GM-Tg-mg-T46456-Ab-1/ GM-Tg-mg-T46456-Ab-2; GM-Tg-cynog-T46456-Ab-1/ GM-Tg-cynog-T46456-Ab-2; GM-Tg-felg-T46456-Ab-1/ GM-Tg-felg-T46456-Ab-2; GM-Tg-cang-T46456-Ab-1/ GM-Tg-cang-T46456-Ab-2; GM-Tg-bovg-T46456-Ab-1/ GM-Tg-bovg-T46456-Ab-2; GM-Tg-equg-T46456-Ab-1/ GM-Tg-equg-T46456-Ab-2 |
| Products Name | Anti-RXRG monoclonal antibody |
| Format | mab |
| Target Name | RXRG |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RXRG monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T46456-Ag-1 | Recombinant multi-species RXRG/ NR2B3/ RXRC protein |
| ORF Viral Vector | vGMLP000654 | human RXRG Lentivirus particle |
| ORF Viral Vector | pGMLP000654 | human RXRG Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002195 | mouse Rxrg Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002195 | mouse Rxrg Lentivirus particle |
Target information
| Target ID | GM-T46456 |
| Target Name | RXRG |
| Gene ID | 6258,20183,83574,694807,478989,101081273,509500,100060371 |
| Gene Symbol and Synonyms | NR2B3,RXR-gamma,RXRC,RXRG,RXRgamma |
| Uniprot Accession | P48443,Q5BJR8,Q0VC20 |
| Uniprot Entry Name | RXRG_HUMAN,RXRG_RAT,RXRG_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000143171 |
| Target Classification | Nuclear Receptors |
The target: RXRG, gene name: RXRG, also named as NR2B3, RXRC. This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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