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Anti-HPSE/ HPA/ HPA1 functional antibody
Anti-HPSE/ HPA/ HPA1 functional antibody for cell culture, ELISA & in-vivo assay
Go to HPSE/HPSE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T47623-Ab-1/ GM-Tg-hg-T47623-Ab-2 | Anti-Human HPSE monoclonal antibody | Human |
| GM-Tg-rg-T47623-Ab-1/ GM-Tg-rg-T47623-Ab-2 | Anti-Rat HPSE monoclonal antibody | Rat |
| GM-Tg-mg-T47623-Ab-1/ GM-Tg-mg-T47623-Ab-2 | Anti-Mouse HPSE monoclonal antibody | Mouse |
| GM-Tg-cynog-T47623-Ab-1/ GM-Tg-cynog-T47623-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HPSE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T47623-Ab-1/ GM-Tg-felg-T47623-Ab-2 | Anti-Feline HPSE monoclonal antibody | Feline |
| GM-Tg-cang-T47623-Ab-1/ GM-Tg-cang-T47623-Ab-2 | Anti-Canine HPSE monoclonal antibody | Canine |
| GM-Tg-bovg-T47623-Ab-1/ GM-Tg-bovg-T47623-Ab-2 | Anti-Bovine HPSE monoclonal antibody | Bovine |
| GM-Tg-equg-T47623-Ab-1/ GM-Tg-equg-T47623-Ab-2 | Anti-Equine HPSE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T47623-Ab-1/ GM-Tg-hg-T47623-Ab-2; GM-Tg-rg-T47623-Ab-1/ GM-Tg-rg-T47623-Ab-2; GM-Tg-mg-T47623-Ab-1/ GM-Tg-mg-T47623-Ab-2; GM-Tg-cynog-T47623-Ab-1/ GM-Tg-cynog-T47623-Ab-2; GM-Tg-felg-T47623-Ab-1/ GM-Tg-felg-T47623-Ab-2; GM-Tg-cang-T47623-Ab-1/ GM-Tg-cang-T47623-Ab-2; GM-Tg-bovg-T47623-Ab-1/ GM-Tg-bovg-T47623-Ab-2; GM-Tg-equg-T47623-Ab-1/ GM-Tg-equg-T47623-Ab-2 |
| Products Name | Anti-HPSE monoclonal antibody |
| Format | mab |
| Target Name | HPSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HPSE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T47623-Ag-1 | Recombinant multi-species HPSE/ HPA/ HPA1 protein |
| ORF Viral Vector | pGMLP001128 | human HPSE Lentivirus plasmid |
| ORF Viral Vector | vGMLP001128 | human HPSE Lentivirus particle |
| ORF Viral Vector | pGMAD000572 | house mouse Hpse Adenovirus plasmid |
| ORF Viral Vector | vGMAD000572 | house mouse Hpse Adenovirus particle |
Target information
| Target ID | GM-T47623 |
| Target Name | HPSE |
| Gene ID | 10855,15442,64537,707583,608707,101090101,281230,100061267 |
| Gene Symbol and Synonyms | Hep,HPA,HPA1,HPR1,HPSE,HPSE1,HSE1 |
| Uniprot Accession | Q9Y251,Q71RP1,Q9MYY0 |
| Uniprot Entry Name | HPSE_HUMAN,HPSE_RAT,HPSE_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000173083 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: HPSE, gene name: HPSE, also named as HPA, HPA1, HPR11, HSE1, HPSE. Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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