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Anti-CAH4/ CA-IV/ CA4 monoclonal antibody
Anti-CAH4/ CA-IV/ CA4 antibody for FACS & in-vivo assay
Go to CA-IV/CA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53378-Ab-1/ GM-Tg-hg-T53378-Ab-2 | Anti-Human CA-IV/CA4 monoclonal antibody | Human |
| GM-Tg-rg-T53378-Ab-1/ GM-Tg-rg-T53378-Ab-2 | Anti-Rat CA-IV/CA4 monoclonal antibody | Rat |
| GM-Tg-mg-T53378-Ab-1/ GM-Tg-mg-T53378-Ab-2 | Anti-Mouse CA-IV/CA4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T53378-Ab-1/ GM-Tg-cynog-T53378-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CA-IV/CA4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53378-Ab-1/ GM-Tg-felg-T53378-Ab-2 | Anti-Feline CA-IV/CA4 monoclonal antibody | Feline |
| GM-Tg-cang-T53378-Ab-1/ GM-Tg-cang-T53378-Ab-2 | Anti-Canine CA-IV/CA4 monoclonal antibody | Canine |
| GM-Tg-bovg-T53378-Ab-1/ GM-Tg-bovg-T53378-Ab-2 | Anti-Bovine CA-IV/CA4 monoclonal antibody | Bovine |
| GM-Tg-equg-T53378-Ab-1/ GM-Tg-equg-T53378-Ab-2 | Anti-Equine CA-IV/CA4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53378-Ab-1/ GM-Tg-hg-T53378-Ab-2; GM-Tg-rg-T53378-Ab-1/ GM-Tg-rg-T53378-Ab-2; GM-Tg-mg-T53378-Ab-1/ GM-Tg-mg-T53378-Ab-2; GM-Tg-cynog-T53378-Ab-1/ GM-Tg-cynog-T53378-Ab-2; GM-Tg-felg-T53378-Ab-1/ GM-Tg-felg-T53378-Ab-2; GM-Tg-cang-T53378-Ab-1/ GM-Tg-cang-T53378-Ab-2; GM-Tg-bovg-T53378-Ab-1/ GM-Tg-bovg-T53378-Ab-2; GM-Tg-equg-T53378-Ab-1/ GM-Tg-equg-T53378-Ab-2 |
| Products Name | Anti-CA-IV/CA4 monoclonal antibody |
| Format | mab |
| Target Name | CA-IV |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CA-IV benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CAH4/ CA-IV/ CA4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002307 | human CA4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002307 | human CA4 Lentivirus particle |
| ORF Viral Vector | pGMLPm000659 | mouse Car4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000659 | mouse Car4 Lentivirus particle |
Target information
| Target ID | GM-T53378 |
| Target Name | CA-IV |
| Gene ID | 762,12351,29242,716919,480591,101088531,280741,100071384 |
| Gene Symbol and Synonyms | CA4,CAIV,Car4,RP17 |
| Uniprot Accession | P22748,P48284,Q95323 |
| Uniprot Entry Name | CAH4_HUMAN,CAH4_RAT,CAH4_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000167434 |
| Target Classification | N/A |
The target: CA-IV, gene name: CA4, also named as CAIV, Car4, RP17. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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