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Anti-PGFRA/ PDGFRA/ CD140A monoclonal antibody
Anti-PGFRA/ PDGFRA/ CD140A antibody for FACS & in-vivo assay
Go to PDGFRA/PDGFRA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53524-Ab-1/ GM-Tg-hg-T53524-Ab-2 | Anti-Human PDGFRA monoclonal antibody | Human |
| GM-Tg-rg-T53524-Ab-1/ GM-Tg-rg-T53524-Ab-2 | Anti-Rat PDGFRA monoclonal antibody | Rat |
| GM-Tg-mg-T53524-Ab-1/ GM-Tg-mg-T53524-Ab-2 | Anti-Mouse PDGFRA monoclonal antibody | Mouse |
| GM-Tg-cynog-T53524-Ab-1/ GM-Tg-cynog-T53524-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDGFRA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53524-Ab-1/ GM-Tg-felg-T53524-Ab-2 | Anti-Feline PDGFRA monoclonal antibody | Feline |
| GM-Tg-cang-T53524-Ab-1/ GM-Tg-cang-T53524-Ab-2 | Anti-Canine PDGFRA monoclonal antibody | Canine |
| GM-Tg-bovg-T53524-Ab-1/ GM-Tg-bovg-T53524-Ab-2 | Anti-Bovine PDGFRA monoclonal antibody | Bovine |
| GM-Tg-equg-T53524-Ab-1/ GM-Tg-equg-T53524-Ab-2 | Anti-Equine PDGFRA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53524-Ab-1/ GM-Tg-hg-T53524-Ab-2; GM-Tg-rg-T53524-Ab-1/ GM-Tg-rg-T53524-Ab-2; GM-Tg-mg-T53524-Ab-1/ GM-Tg-mg-T53524-Ab-2; GM-Tg-cynog-T53524-Ab-1/ GM-Tg-cynog-T53524-Ab-2; GM-Tg-felg-T53524-Ab-1/ GM-Tg-felg-T53524-Ab-2; GM-Tg-cang-T53524-Ab-1/ GM-Tg-cang-T53524-Ab-2; GM-Tg-bovg-T53524-Ab-1/ GM-Tg-bovg-T53524-Ab-2; GM-Tg-equg-T53524-Ab-1/ GM-Tg-equg-T53524-Ab-2 |
| Products Name | Anti-PDGFRA monoclonal antibody |
| Format | mab |
| Target Name | PDGFRA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDGFRA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-393 | Pre-Made Olaratumab biosimilar, Whole mAb, Anti-PDGFRA Antibody: Anti-CD140A/PDGFR-2/PDGFR2 therapeutic antibody |
| Biosimilar | GMP-Bios-ab-590 | Pre-Made Tovetumab biosimilar, Whole mAb, Anti-PDGFRA Antibody: Anti-CD140A/PDGFR-2/PDGFR2 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species PGFRA/ PDGFRA/ CD140A VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T53524-Ag-1 | Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of theplatelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiat (PDGFRA) protein |
| ORF Viral Vector | vGMAP000154 | Human PDGFRA Adenovirus particle |
| ORF Viral Vector | pGMAP000154 | Human PDGFRA Adenovirus plasmid |
Target information
| Target ID | GM-T53524 |
| Target Name | PDGFRA |
| Gene ID | 5156,18595,25267,697002,442860,101090765,282301,100059815 |
| Gene Symbol and Synonyms | APDGFR,CD140A,PDGFACE,PDGFR-2,PDGFR2,PDGFRA |
| Uniprot Accession | P16234,P20786 |
| Uniprot Entry Name | PGFRA_HUMAN,PGFRA_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Non-Small Cell Lung Cancer |
| Gene Ensembl | ENSG00000134853 |
| Target Classification | N/A |
The target: PDGFRA, gene name: PDGFRA, also named as CD140A, PDGFR-2, PDGFR2. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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