Anti-ASIC1/ ACCN2/ ASIC monoclonal antibody

Anti-ASIC1/ ACCN2/ ASIC antibody for FACS & in-vivo assay

Target products collectionGo to ASIC1/ASIC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T55094-Ab-1/ GM-Tg-hg-T55094-Ab-2Anti-Human ASIC1 monoclonal antibodyHuman
GM-Tg-rg-T55094-Ab-1/ GM-Tg-rg-T55094-Ab-2Anti-Rat ASIC1 monoclonal antibodyRat
GM-Tg-mg-T55094-Ab-1/ GM-Tg-mg-T55094-Ab-2Anti-Mouse ASIC1 monoclonal antibodyMouse
GM-Tg-cynog-T55094-Ab-1/ GM-Tg-cynog-T55094-Ab-2Anti-Cynomolgus/ Rhesus macaque ASIC1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T55094-Ab-1/ GM-Tg-felg-T55094-Ab-2Anti-Feline ASIC1 monoclonal antibodyFeline
GM-Tg-cang-T55094-Ab-1/ GM-Tg-cang-T55094-Ab-2Anti-Canine ASIC1 monoclonal antibodyCanine
GM-Tg-bovg-T55094-Ab-1/ GM-Tg-bovg-T55094-Ab-2Anti-Bovine ASIC1 monoclonal antibodyBovine
GM-Tg-equg-T55094-Ab-1/ GM-Tg-equg-T55094-Ab-2Anti-Equine ASIC1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T55094-Ab-1/ GM-Tg-hg-T55094-Ab-2; GM-Tg-rg-T55094-Ab-1/ GM-Tg-rg-T55094-Ab-2;
GM-Tg-mg-T55094-Ab-1/ GM-Tg-mg-T55094-Ab-2; GM-Tg-cynog-T55094-Ab-1/ GM-Tg-cynog-T55094-Ab-2;
GM-Tg-felg-T55094-Ab-1/ GM-Tg-felg-T55094-Ab-2; GM-Tg-cang-T55094-Ab-1/ GM-Tg-cang-T55094-Ab-2;
GM-Tg-bovg-T55094-Ab-1/ GM-Tg-bovg-T55094-Ab-2; GM-Tg-equg-T55094-Ab-1/ GM-Tg-equg-T55094-Ab-2
Products NameAnti-ASIC1 monoclonal antibody
Formatmab
Target NameASIC1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ASIC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ASIC1/ ACCN2/ ASIC VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000085human ASIC1 Lentivirus particle
    ORF Viral VectorpGMLP003358human ASIC1 Lentivirus plasmid
    ORF Viral VectorpGMLV000085human ASIC1 Lentivirus plasmid
    ORF Viral VectorvGMLP003358human ASIC1 Lentivirus particle
    ORF Viral VectorpGMLPm004382mouse Asic1 Lentivirus plasmid
    ORF Viral VectorvGMLPm004382mouse Asic1 Lentivirus particle


    Target information

    Target IDGM-T55094
    Target NameASIC1
    Gene ID41,11419,79123,713320,477612,101085729,538244,100630368
    Gene Symbol and SynonymsACCN2,ASIC,ASIC1,ASIC1a,ASIC1b,B530003N02Rik,BNaC2
    Uniprot AccessionP78348,P55926
    Uniprot Entry NameASIC1_HUMAN,ASIC1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000110881
    Target ClassificationN/A

    The target: ASIC1, gene name: ASIC1, also named as ACCN2, ASIC, BNaC2. This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.