Anti-V1BR/ AVPR1B/ AVPR3 monoclonal antibody
Anti-V1BR/ AVPR1B/ AVPR3 antibody for FACS & in-vivo assay
Go to V1BR/AVPR1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T59881-Ab-1/ GM-Tg-hg-T59881-Ab-2 | Anti-Human V1BR/AVPR1B monoclonal antibody | Human |
GM-Tg-rg-T59881-Ab-1/ GM-Tg-rg-T59881-Ab-2 | Anti-Rat V1BR/AVPR1B monoclonal antibody | Rat |
GM-Tg-mg-T59881-Ab-1/ GM-Tg-mg-T59881-Ab-2 | Anti-Mouse V1BR/AVPR1B monoclonal antibody | Mouse |
GM-Tg-cynog-T59881-Ab-1/ GM-Tg-cynog-T59881-Ab-2 | Anti-Cynomolgus/ Rhesus macaque V1BR/AVPR1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T59881-Ab-1/ GM-Tg-felg-T59881-Ab-2 | Anti-Feline V1BR/AVPR1B monoclonal antibody | Feline |
GM-Tg-cang-T59881-Ab-1/ GM-Tg-cang-T59881-Ab-2 | Anti-Canine V1BR/AVPR1B monoclonal antibody | Canine |
GM-Tg-bovg-T59881-Ab-1/ GM-Tg-bovg-T59881-Ab-2 | Anti-Bovine V1BR/AVPR1B monoclonal antibody | Bovine |
GM-Tg-equg-T59881-Ab-1/ GM-Tg-equg-T59881-Ab-2 | Anti-Equine V1BR/AVPR1B monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T59881-Ab-1/ GM-Tg-hg-T59881-Ab-2; GM-Tg-rg-T59881-Ab-1/ GM-Tg-rg-T59881-Ab-2; GM-Tg-mg-T59881-Ab-1/ GM-Tg-mg-T59881-Ab-2; GM-Tg-cynog-T59881-Ab-1/ GM-Tg-cynog-T59881-Ab-2; GM-Tg-felg-T59881-Ab-1/ GM-Tg-felg-T59881-Ab-2; GM-Tg-cang-T59881-Ab-1/ GM-Tg-cang-T59881-Ab-2; GM-Tg-bovg-T59881-Ab-1/ GM-Tg-bovg-T59881-Ab-2; GM-Tg-equg-T59881-Ab-1/ GM-Tg-equg-T59881-Ab-2 |
Products Name | Anti-V1BR/AVPR1B monoclonal antibody |
Format | mab |
Target Name | V1BR |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-V1BR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species V1BR/ AVPR1B/ AVPR3 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP001606 | human AVPR1B Lentivirus particle |
ORF Viral Vector | pGMLP001606 | human AVPR1B Lentivirus plasmid |
ORF Viral Vector | pGMLPm005148 | mouse Avpr1b Lentivirus plasmid |
ORF Viral Vector | vGMLPm005148 | mouse Avpr1b Lentivirus particle |
Target information
Target ID | GM-T59881 |
Target Name | V1BR |
Gene ID | 553,26361,100909648,695963,488578,101088713,282861,100055260 |
Gene Symbol and Synonyms | AVPR V1b,AVPR V3,AVPR1B,AVPR3,V1bR,V3/V1b,VIBR,VPR3 |
Uniprot Accession | P47901,P48974 |
Uniprot Entry Name | V1BR_HUMAN,V1BR_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000198049 |
Target Classification | N/A |
The target: V1BR, gene name: AVPR1B, also named as AVPR3, V1bR. The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.