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Anti-TSHR/ CHNG1/ LGR3 monoclonal antibody
Anti-TSHR/ CHNG1/ LGR3 antibody for FACS & in-vivo assay
Go to TSHR/TSHR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T60606-Ab-1/ GM-Tg-hg-T60606-Ab-2 | Anti-Human TSHR monoclonal antibody | Human |
| GM-Tg-rg-T60606-Ab-1/ GM-Tg-rg-T60606-Ab-2 | Anti-Rat TSHR monoclonal antibody | Rat |
| GM-Tg-mg-T60606-Ab-1/ GM-Tg-mg-T60606-Ab-2 | Anti-Mouse TSHR monoclonal antibody | Mouse |
| GM-Tg-cynog-T60606-Ab-1/ GM-Tg-cynog-T60606-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TSHR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T60606-Ab-1/ GM-Tg-felg-T60606-Ab-2 | Anti-Feline TSHR monoclonal antibody | Feline |
| GM-Tg-cang-T60606-Ab-1/ GM-Tg-cang-T60606-Ab-2 | Anti-Canine TSHR monoclonal antibody | Canine |
| GM-Tg-bovg-T60606-Ab-1/ GM-Tg-bovg-T60606-Ab-2 | Anti-Bovine TSHR monoclonal antibody | Bovine |
| GM-Tg-equg-T60606-Ab-1/ GM-Tg-equg-T60606-Ab-2 | Anti-Equine TSHR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T60606-Ab-1/ GM-Tg-hg-T60606-Ab-2; GM-Tg-rg-T60606-Ab-1/ GM-Tg-rg-T60606-Ab-2; GM-Tg-mg-T60606-Ab-1/ GM-Tg-mg-T60606-Ab-2; GM-Tg-cynog-T60606-Ab-1/ GM-Tg-cynog-T60606-Ab-2; GM-Tg-felg-T60606-Ab-1/ GM-Tg-felg-T60606-Ab-2; GM-Tg-cang-T60606-Ab-1/ GM-Tg-cang-T60606-Ab-2; GM-Tg-bovg-T60606-Ab-1/ GM-Tg-bovg-T60606-Ab-2; GM-Tg-equg-T60606-Ab-1/ GM-Tg-equg-T60606-Ab-2 |
| Products Name | Anti-TSHR monoclonal antibody |
| Format | mab |
| Target Name | TSHR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TSHR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TSHR/ CHNG1/ LGR3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000258 | Human TSHR Adenovirus particle |
| ORF Viral Vector | pGMAP000258 | Human TSHR Adenovirus plasmid |
Target information
| Target ID | GM-T60606 |
| Target Name | TSHR |
| Gene ID | 7253,22095,25360,574251,403968,493842,281553,111770367 |
| Gene Symbol and Synonyms | CHNG1,hTSHR-I,hypothroid,hyt,LGR3,pet,TSH-R,TSHR,TSHRA |
| Uniprot Accession | P16473,P21463,P14763,Q9BGN4,Q27987 |
| Uniprot Entry Name | TSHR_HUMAN,TSHR_RAT,TSHR_FELCA,TSHR_CANLF,TSHR_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000165409 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA) |
The target: TSHR, gene name: TSHR, also named as CHNG1, LGR3, hTSHR-I. The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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