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Anti-AKR1C3 monoclonal antibody
Pre-made anti-AKR1C3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to AKR1C3/AKR1C3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T60857-Ab-1/ GM-Tg-hg-T60857-Ab-2 | Anti-Human AKR1C3 monoclonal antibody | Human |
| GM-Tg-rg-T60857-Ab-1/ GM-Tg-rg-T60857-Ab-2 | Anti-Rat AKR1C3 monoclonal antibody | Rat |
| GM-Tg-mg-T60857-Ab-1/ GM-Tg-mg-T60857-Ab-2 | Anti-Mouse AKR1C3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T60857-Ab-1/ GM-Tg-cynog-T60857-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AKR1C3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T60857-Ab-1/ GM-Tg-felg-T60857-Ab-2 | Anti-Feline AKR1C3 monoclonal antibody | Feline |
| GM-Tg-cang-T60857-Ab-1/ GM-Tg-cang-T60857-Ab-2 | Anti-Canine AKR1C3 monoclonal antibody | Canine |
| GM-Tg-bovg-T60857-Ab-1/ GM-Tg-bovg-T60857-Ab-2 | Anti-Bovine AKR1C3 monoclonal antibody | Bovine |
| GM-Tg-equg-T60857-Ab-1/ GM-Tg-equg-T60857-Ab-2 | Anti-Equine AKR1C3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T60857-Ab-1/ GM-Tg-hg-T60857-Ab-2; GM-Tg-rg-T60857-Ab-1/ GM-Tg-rg-T60857-Ab-2; GM-Tg-mg-T60857-Ab-1/ GM-Tg-mg-T60857-Ab-2; GM-Tg-cynog-T60857-Ab-1/ GM-Tg-cynog-T60857-Ab-2; GM-Tg-felg-T60857-Ab-1/ GM-Tg-felg-T60857-Ab-2; GM-Tg-cang-T60857-Ab-1/ GM-Tg-cang-T60857-Ab-2; GM-Tg-bovg-T60857-Ab-1/ GM-Tg-bovg-T60857-Ab-2; GM-Tg-equg-T60857-Ab-1/ GM-Tg-equg-T60857-Ab-2 |
| Products Name | Anti-AKR1C3 monoclonal antibody |
| Format | mab |
| Target Name | AKR1C3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-AKR1C3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T60857-Ag-1 | Recombinant multi-species AK1C3/ AKR1C3/ DD3 protein |
Target information
| Target ID | GM-T60857 |
| Target Name | AKR1C3 |
| Gene ID | 8644 |
| Gene Symbol and Synonyms | AKR1C3,DD3,DDX,HA1753,HAKRB,HAKRe,hluPGFS,HSD17B5,PGFS |
| Uniprot Accession | P42330 |
| Uniprot Entry Name | AK1C3_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000196139 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: AKR1C3, gene name: AKR1C3, also named as DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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