Anti-PDE4A/ DPDE2/ PDE4 monoclonal antibody

Anti-PDE4A/ DPDE2/ PDE4 antibody for FACS & in-vivo assay

Target products collectionGo to PDE4A/PDE4A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T61744-Ab-1/ GM-Tg-hg-T61744-Ab-2Anti-Human PDE4A monoclonal antibodyHuman
GM-Tg-rg-T61744-Ab-1/ GM-Tg-rg-T61744-Ab-2Anti-Rat PDE4A monoclonal antibodyRat
GM-Tg-mg-T61744-Ab-1/ GM-Tg-mg-T61744-Ab-2Anti-Mouse PDE4A monoclonal antibodyMouse
GM-Tg-cynog-T61744-Ab-1/ GM-Tg-cynog-T61744-Ab-2Anti-Cynomolgus/ Rhesus macaque PDE4A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T61744-Ab-1/ GM-Tg-felg-T61744-Ab-2Anti-Feline PDE4A monoclonal antibodyFeline
GM-Tg-cang-T61744-Ab-1/ GM-Tg-cang-T61744-Ab-2Anti-Canine PDE4A monoclonal antibodyCanine
GM-Tg-bovg-T61744-Ab-1/ GM-Tg-bovg-T61744-Ab-2Anti-Bovine PDE4A monoclonal antibodyBovine
GM-Tg-equg-T61744-Ab-1/ GM-Tg-equg-T61744-Ab-2Anti-Equine PDE4A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T61744-Ab-1/ GM-Tg-hg-T61744-Ab-2; GM-Tg-rg-T61744-Ab-1/ GM-Tg-rg-T61744-Ab-2;
GM-Tg-mg-T61744-Ab-1/ GM-Tg-mg-T61744-Ab-2; GM-Tg-cynog-T61744-Ab-1/ GM-Tg-cynog-T61744-Ab-2;
GM-Tg-felg-T61744-Ab-1/ GM-Tg-felg-T61744-Ab-2; GM-Tg-cang-T61744-Ab-1/ GM-Tg-cang-T61744-Ab-2;
GM-Tg-bovg-T61744-Ab-1/ GM-Tg-bovg-T61744-Ab-2; GM-Tg-equg-T61744-Ab-1/ GM-Tg-equg-T61744-Ab-2
Products NameAnti-PDE4A monoclonal antibody
Formatmab
Target NamePDE4A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PDE4A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PDE4A/ DPDE2/ PDE4 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T61744
    Target NamePDE4A
    Gene ID5141,18577,25638,712850,100683695,751107,512222,100147080
    Gene Symbol and SynonymsD9Ertd60e,DPDE2,PDE4,PDE46,PDE4A,PHOSA
    Uniprot AccessionP27815,P54748
    Uniprot Entry NamePDE4A_HUMAN,PDE4A_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000065989
    Target ClassificationN/A

    The target: PDE4A, gene name: PDE4A, also named as DPDE2, PDE4, PDE46. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.