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Anti-MANF/ ARMET/ ARP functional antibody
Anti-MANF/ ARMET/ ARP functional antibody for cell culture, ELISA & in-vivo assay
Go to ARMET/MANF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T62415-Ab-1/ GM-Tg-hg-T62415-Ab-2 | Anti-Human ARMET/MANF monoclonal antibody | Human |
| GM-Tg-rg-T62415-Ab-1/ GM-Tg-rg-T62415-Ab-2 | Anti-Rat ARMET/MANF monoclonal antibody | Rat |
| GM-Tg-mg-T62415-Ab-1/ GM-Tg-mg-T62415-Ab-2 | Anti-Mouse ARMET/MANF monoclonal antibody | Mouse |
| GM-Tg-cynog-T62415-Ab-1/ GM-Tg-cynog-T62415-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ARMET/MANF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T62415-Ab-1/ GM-Tg-felg-T62415-Ab-2 | Anti-Feline ARMET/MANF monoclonal antibody | Feline |
| GM-Tg-cang-T62415-Ab-1/ GM-Tg-cang-T62415-Ab-2 | Anti-Canine ARMET/MANF monoclonal antibody | Canine |
| GM-Tg-bovg-T62415-Ab-1/ GM-Tg-bovg-T62415-Ab-2 | Anti-Bovine ARMET/MANF monoclonal antibody | Bovine |
| GM-Tg-equg-T62415-Ab-1/ GM-Tg-equg-T62415-Ab-2 | Anti-Equine ARMET/MANF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T62415-Ab-1/ GM-Tg-hg-T62415-Ab-2; GM-Tg-rg-T62415-Ab-1/ GM-Tg-rg-T62415-Ab-2; GM-Tg-mg-T62415-Ab-1/ GM-Tg-mg-T62415-Ab-2; GM-Tg-cynog-T62415-Ab-1/ GM-Tg-cynog-T62415-Ab-2; GM-Tg-felg-T62415-Ab-1/ GM-Tg-felg-T62415-Ab-2; GM-Tg-cang-T62415-Ab-1/ GM-Tg-cang-T62415-Ab-2; GM-Tg-bovg-T62415-Ab-1/ GM-Tg-bovg-T62415-Ab-2; GM-Tg-equg-T62415-Ab-1/ GM-Tg-equg-T62415-Ab-2 |
| Products Name | Anti-ARMET/MANF monoclonal antibody |
| Format | mab |
| Target Name | ARMET |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ARMET benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T62415-Ag-1 | Recombinant multi-species MANF/ ARMET/ ARP protein |
| ORF Viral Vector | pGMLP003144 | human MANF Lentivirus plasmid |
| ORF Viral Vector | vGMLV000783 | human MANF Lentivirus particle |
| ORF Viral Vector | vGMLP003144 | human MANF Lentivirus particle |
| ORF Viral Vector | pGMLV000783 | human MANF Lentivirus plasmid |
| ORF Viral Vector | pGMLV000199 | human MANF Lentivirus plasmid |
| ORF Viral Vector | vGMLV000199 | human MANF Lentivirus particle |
| ORF Viral Vector | pGMAAV000251 | house mouse Manf AAV plasmid |
| ORF Viral Vector | pGMLPm005119 | mouse Manf Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000251 | house mouse Manf AAV particle |
| ORF Viral Vector | vGMLPm005119 | mouse Manf Lentivirus particle |
Target information
| Target ID | GM-T62415 |
| Target Name | ARMET |
| Gene ID | 7873,74840,315989,700659,100855747,101090926,540432,100052301 |
| Gene Symbol and Synonyms | 3230402M22Rik,ARMET,ARP,D18Mgi17,MANF |
| Uniprot Accession | P55145,P0C5H9,P80513 |
| Uniprot Entry Name | MANF_HUMAN,MANF_RAT,MANF_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000145050 |
| Target Classification | N/A |
The target: ARMET, gene name: MANF, also named as ARMET, ARP. The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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