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Anti-GPER1/ CEPR/ CMKRL2 monoclonal antibody
Anti-GPER1/ CEPR/ CMKRL2 antibody for FACS & in-vivo assay
Go to GPER1/GPER1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T65236-Ab-1/ GM-Tg-hg-T65236-Ab-2 | Anti-Human GPER1 monoclonal antibody | Human |
| GM-Tg-rg-T65236-Ab-1/ GM-Tg-rg-T65236-Ab-2 | Anti-Rat GPER1 monoclonal antibody | Rat |
| GM-Tg-mg-T65236-Ab-1/ GM-Tg-mg-T65236-Ab-2 | Anti-Mouse GPER1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T65236-Ab-1/ GM-Tg-cynog-T65236-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GPER1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T65236-Ab-1/ GM-Tg-felg-T65236-Ab-2 | Anti-Feline GPER1 monoclonal antibody | Feline |
| GM-Tg-cang-T65236-Ab-1/ GM-Tg-cang-T65236-Ab-2 | Anti-Canine GPER1 monoclonal antibody | Canine |
| GM-Tg-bovg-T65236-Ab-1/ GM-Tg-bovg-T65236-Ab-2 | Anti-Bovine GPER1 monoclonal antibody | Bovine |
| GM-Tg-equg-T65236-Ab-1/ GM-Tg-equg-T65236-Ab-2 | Anti-Equine GPER1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T65236-Ab-1/ GM-Tg-hg-T65236-Ab-2; GM-Tg-rg-T65236-Ab-1/ GM-Tg-rg-T65236-Ab-2; GM-Tg-mg-T65236-Ab-1/ GM-Tg-mg-T65236-Ab-2; GM-Tg-cynog-T65236-Ab-1/ GM-Tg-cynog-T65236-Ab-2; GM-Tg-felg-T65236-Ab-1/ GM-Tg-felg-T65236-Ab-2; GM-Tg-cang-T65236-Ab-1/ GM-Tg-cang-T65236-Ab-2; GM-Tg-bovg-T65236-Ab-1/ GM-Tg-bovg-T65236-Ab-2; GM-Tg-equg-T65236-Ab-1/ GM-Tg-equg-T65236-Ab-2 |
| Products Name | Anti-GPER1 monoclonal antibody |
| Format | mab |
| Target Name | GPER1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GPER1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GPER1/ CEPR/ CMKRL2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000420 | human GPER1 Lentivirus particle |
| ORF Viral Vector | pGMLV000420 | human GPER1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001438 | mouse Gper1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001438 | mouse Gper1 Lentivirus particle |
Target information
| Target ID | GM-T65236 |
| Target Name | GPER1 |
| Gene ID | 2852,76854,171104,696625,480808,101085767,527831,102148430 |
| Gene Symbol and Synonyms | 6330420K13Rik,CEPR,Ceprl,CMKRL2,DRY12,FEG-1,GPCR-Br,GPER,GPER1,GPR30,GPR41,LERGU,LERGU2,LyGPR,mER |
| Uniprot Accession | Q99527,O08878,F7EQ49 |
| Uniprot Entry Name | GPER1_HUMAN,GPER1_MACMU,GPER1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000164850 |
| Target Classification | GPCR, Tumor-associated antigen (TAA) |
The target: GPER1, gene name: GPER1, also named as CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER. This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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