Anti-ROS1/ MCF3/ ROS monoclonal antibody

Anti-ROS1/ MCF3/ ROS antibody for FACS & in-vivo assay

Target products collectionGo to ROS1/ROS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T69128-Ab-1/ GM-Tg-hg-T69128-Ab-2Anti-Human ROS1 monoclonal antibodyHuman
GM-Tg-rg-T69128-Ab-1/ GM-Tg-rg-T69128-Ab-2Anti-Rat ROS1 monoclonal antibodyRat
GM-Tg-mg-T69128-Ab-1/ GM-Tg-mg-T69128-Ab-2Anti-Mouse ROS1 monoclonal antibodyMouse
GM-Tg-cynog-T69128-Ab-1/ GM-Tg-cynog-T69128-Ab-2Anti-Cynomolgus/ Rhesus macaque ROS1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T69128-Ab-1/ GM-Tg-felg-T69128-Ab-2Anti-Feline ROS1 monoclonal antibodyFeline
GM-Tg-cang-T69128-Ab-1/ GM-Tg-cang-T69128-Ab-2Anti-Canine ROS1 monoclonal antibodyCanine
GM-Tg-bovg-T69128-Ab-1/ GM-Tg-bovg-T69128-Ab-2Anti-Bovine ROS1 monoclonal antibodyBovine
GM-Tg-equg-T69128-Ab-1/ GM-Tg-equg-T69128-Ab-2Anti-Equine ROS1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T69128-Ab-1/ GM-Tg-hg-T69128-Ab-2; GM-Tg-rg-T69128-Ab-1/ GM-Tg-rg-T69128-Ab-2;
GM-Tg-mg-T69128-Ab-1/ GM-Tg-mg-T69128-Ab-2; GM-Tg-cynog-T69128-Ab-1/ GM-Tg-cynog-T69128-Ab-2;
GM-Tg-felg-T69128-Ab-1/ GM-Tg-felg-T69128-Ab-2; GM-Tg-cang-T69128-Ab-1/ GM-Tg-cang-T69128-Ab-2;
GM-Tg-bovg-T69128-Ab-1/ GM-Tg-bovg-T69128-Ab-2; GM-Tg-equg-T69128-Ab-1/ GM-Tg-equg-T69128-Ab-2
Products NameAnti-ROS1 monoclonal antibody
Formatmab
Target NameROS1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ROS1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ROS1/ MCF3/ ROS VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T69128
    Target NameROS1
    Gene ID6098,19886,25346,715284,484098,101093437,100336768,100067115
    Gene Symbol and Synonymsc-ros,c-ros-1,MCF3,ROS,Ros-1,ROS1,ROS1C
    Uniprot AccessionP08922,Q63132
    Uniprot Entry NameROS1_HUMAN,ROS1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseNon-Small Cell Lung Cancer
    Gene EnsemblENSG00000047936
    Target ClassificationKinase

    The target: ROS1, gene name: ROS1, also named as MCF3, ROS, c-ros-1. This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.