Anti-5HT1A/ HTR1A/ 5-HT-1A monoclonal antibody

Anti-5HT1A/ HTR1A/ 5-HT-1A antibody for FACS & in-vivo assay

Target products collectionGo to HTR1A/HTR1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T78709-Ab-1/ GM-Tg-hg-T78709-Ab-2Anti-Human HTR1A monoclonal antibodyHuman
GM-Tg-rg-T78709-Ab-1/ GM-Tg-rg-T78709-Ab-2Anti-Rat HTR1A monoclonal antibodyRat
GM-Tg-mg-T78709-Ab-1/ GM-Tg-mg-T78709-Ab-2Anti-Mouse HTR1A monoclonal antibodyMouse
GM-Tg-cynog-T78709-Ab-1/ GM-Tg-cynog-T78709-Ab-2Anti-Cynomolgus/ Rhesus macaque HTR1A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T78709-Ab-1/ GM-Tg-felg-T78709-Ab-2Anti-Feline HTR1A monoclonal antibodyFeline
GM-Tg-cang-T78709-Ab-1/ GM-Tg-cang-T78709-Ab-2Anti-Canine HTR1A monoclonal antibodyCanine
GM-Tg-bovg-T78709-Ab-1/ GM-Tg-bovg-T78709-Ab-2Anti-Bovine HTR1A monoclonal antibodyBovine
GM-Tg-equg-T78709-Ab-1/ GM-Tg-equg-T78709-Ab-2Anti-Equine HTR1A monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T78709-Ab-1/ GM-Tg-hg-T78709-Ab-2; GM-Tg-rg-T78709-Ab-1/ GM-Tg-rg-T78709-Ab-2;
GM-Tg-mg-T78709-Ab-1/ GM-Tg-mg-T78709-Ab-2; GM-Tg-cynog-T78709-Ab-1/ GM-Tg-cynog-T78709-Ab-2;
GM-Tg-felg-T78709-Ab-1/ GM-Tg-felg-T78709-Ab-2; GM-Tg-cang-T78709-Ab-1/ GM-Tg-cang-T78709-Ab-2;
GM-Tg-bovg-T78709-Ab-1/ GM-Tg-bovg-T78709-Ab-2; GM-Tg-equg-T78709-Ab-1/ GM-Tg-equg-T78709-Ab-2
Products NameAnti-HTR1A monoclonal antibody
Formatmab
Target NameHTR1A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HTR1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species 5HT1A/ HTR1A/ 5-HT-1A VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003677human HTR1A Lentivirus plasmid
    ORF Viral VectorvGMLP003677human HTR1A Lentivirus particle
    ORF Viral VectorpGMLPm002988mouse Htr1a Lentivirus plasmid
    ORF Viral VectorvGMLPm002988mouse Htr1a Lentivirus particle


    Target information

    Target IDGM-T78709
    Target NameHTR1A
    Gene ID3350,15550,24473,694991,487230,101101542,407137,100009683
    Gene Symbol and Synonyms5-HT-1A,5-HT1A,5HT1a,5htr1a,ADRB2RL1,ADRBRL1,G-21,Gpcr18,HTR1A,PFMCD,RAT5HT1A
    Uniprot AccessionP08908,P19327,Q6XXX9,Q0EAB6
    Uniprot Entry Name5HT1A_HUMAN,5HT1A_RAT,5HT1A_CANLF,5HT1A_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000178394
    Target ClassificationGPCR

    The target: HTR1A, gene name: HTR1A, also named as 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD. This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.