Anti-ADA17/ ADAM17/ ADAM18 monoclonal antibody
Anti-ADA17/ ADAM17/ ADAM18 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T82393-Ab-1/ GM-Tg-hg-T82393-Ab-2 | Anti-Human ADAM17 monoclonal antibody | Human |
GM-Tg-rg-T82393-Ab-1/ GM-Tg-rg-T82393-Ab-2 | Anti-Rat ADAM17 monoclonal antibody | Rat |
GM-Tg-mg-T82393-Ab-1/ GM-Tg-mg-T82393-Ab-2 | Anti-Mouse ADAM17 monoclonal antibody | Mouse |
GM-Tg-cynog-T82393-Ab-1/ GM-Tg-cynog-T82393-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADAM17 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T82393-Ab-1/ GM-Tg-felg-T82393-Ab-2 | Anti-Feline ADAM17 monoclonal antibody | Feline |
GM-Tg-cang-T82393-Ab-1/ GM-Tg-cang-T82393-Ab-2 | Anti-Canine ADAM17 monoclonal antibody | Canine |
GM-Tg-bovg-T82393-Ab-1/ GM-Tg-bovg-T82393-Ab-2 | Anti-Bovine ADAM17 monoclonal antibody | Bovine |
GM-Tg-equg-T82393-Ab-1/ GM-Tg-equg-T82393-Ab-2 | Anti-Equine ADAM17 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T82393-Ab-1/ GM-Tg-hg-T82393-Ab-2; GM-Tg-rg-T82393-Ab-1/ GM-Tg-rg-T82393-Ab-2; GM-Tg-mg-T82393-Ab-1/ GM-Tg-mg-T82393-Ab-2; GM-Tg-cynog-T82393-Ab-1/ GM-Tg-cynog-T82393-Ab-2; GM-Tg-felg-T82393-Ab-1/ GM-Tg-felg-T82393-Ab-2; GM-Tg-cang-T82393-Ab-1/ GM-Tg-cang-T82393-Ab-2; GM-Tg-bovg-T82393-Ab-1/ GM-Tg-bovg-T82393-Ab-2; GM-Tg-equg-T82393-Ab-1/ GM-Tg-equg-T82393-Ab-2 |
Products Name | Anti-ADAM17 monoclonal antibody |
Format | mab |
Target Name | ADAM17 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-ADAM17 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species ADA17/ ADAM17/ ADAM18 VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T82393 |
Target Name | ADAM17 |
Gene ID | 6868,11491,57027,694429,475662,101089004,517541,100072496 |
Gene Symbol and Synonyms | ADAM17,ADAM18,CD156B,CSVP,NISBD,NISBD1,TACE |
Uniprot Accession | P78536,Q9Z1K9 |
Uniprot Entry Name | ADA17_HUMAN,ADA17_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | Cancer |
Gene Ensembl | ENSG00000151694 |
Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: ADAM17, gene name: ADAM17, also named as ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.