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Anti-5HT2C/ HTR2C/ 5-HT1C monoclonal antibody
Anti-5HT2C/ HTR2C/ 5-HT1C antibody for FACS & in-vivo assay
Go to HTR2C/HTR2C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T83813-Ab-1/ GM-Tg-hg-T83813-Ab-2 | Anti-Human HTR2C monoclonal antibody | Human |
| GM-Tg-rg-T83813-Ab-1/ GM-Tg-rg-T83813-Ab-2 | Anti-Rat HTR2C monoclonal antibody | Rat |
| GM-Tg-mg-T83813-Ab-1/ GM-Tg-mg-T83813-Ab-2 | Anti-Mouse HTR2C monoclonal antibody | Mouse |
| GM-Tg-cynog-T83813-Ab-1/ GM-Tg-cynog-T83813-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTR2C monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T83813-Ab-1/ GM-Tg-felg-T83813-Ab-2 | Anti-Feline HTR2C monoclonal antibody | Feline |
| GM-Tg-cang-T83813-Ab-1/ GM-Tg-cang-T83813-Ab-2 | Anti-Canine HTR2C monoclonal antibody | Canine |
| GM-Tg-bovg-T83813-Ab-1/ GM-Tg-bovg-T83813-Ab-2 | Anti-Bovine HTR2C monoclonal antibody | Bovine |
| GM-Tg-equg-T83813-Ab-1/ GM-Tg-equg-T83813-Ab-2 | Anti-Equine HTR2C monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T83813-Ab-1/ GM-Tg-hg-T83813-Ab-2; GM-Tg-rg-T83813-Ab-1/ GM-Tg-rg-T83813-Ab-2; GM-Tg-mg-T83813-Ab-1/ GM-Tg-mg-T83813-Ab-2; GM-Tg-cynog-T83813-Ab-1/ GM-Tg-cynog-T83813-Ab-2; GM-Tg-felg-T83813-Ab-1/ GM-Tg-felg-T83813-Ab-2; GM-Tg-cang-T83813-Ab-1/ GM-Tg-cang-T83813-Ab-2; GM-Tg-bovg-T83813-Ab-1/ GM-Tg-bovg-T83813-Ab-2; GM-Tg-equg-T83813-Ab-1/ GM-Tg-equg-T83813-Ab-2 |
| Products Name | Anti-HTR2C monoclonal antibody |
| Format | mab |
| Target Name | HTR2C |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HTR2C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species 5HT2C/ HTR2C/ 5-HT1C VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003724 | human HTR2C Lentivirus plasmid |
| ORF Viral Vector | vGMLP003724 | human HTR2C Lentivirus particle |
| ORF Viral Vector | pGMLPm005395 | mouse Htr2c Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005395 | mouse Htr2c Lentivirus particle |
Target information
| Target ID | GM-T83813 |
| Target Name | HTR2C |
| Gene ID | 3358,15560,25187,708141,450240,101099620,538909,100057852 |
| Gene Symbol and Synonyms | 5-HT-1C,5-HT-2C,5-HT1C,5-HT2C,5-HT2cR,5-HTR2C,5HT-1C,5HT1c,5HT2C,5HTR2C,HTR1C,HTR2C,SR1 |
| Uniprot Accession | P28335,P08909,Q60F97 |
| Uniprot Entry Name | 5HT2C_HUMAN,5HT2C_RAT,5HT2C_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000147246 |
| Target Classification | GPCR |
The target: HTR2C, gene name: HTR2C, also named as 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C. This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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