Anti-FA10/ F10/ FX monoclonal antibody

Anti-FA10/ F10/ FX antibody for FACS & in-vivo assay

Target products collectionGo to F10/F10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T84631-Ab-1/ GM-Tg-hg-T84631-Ab-2Anti-Human F10 monoclonal antibodyHuman
GM-Tg-rg-T84631-Ab-1/ GM-Tg-rg-T84631-Ab-2Anti-Rat F10 monoclonal antibodyRat
GM-Tg-mg-T84631-Ab-1/ GM-Tg-mg-T84631-Ab-2Anti-Mouse F10 monoclonal antibodyMouse
GM-Tg-cynog-T84631-Ab-1/ GM-Tg-cynog-T84631-Ab-2Anti-Cynomolgus/ Rhesus macaque F10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T84631-Ab-1/ GM-Tg-felg-T84631-Ab-2Anti-Feline F10 monoclonal antibodyFeline
GM-Tg-cang-T84631-Ab-1/ GM-Tg-cang-T84631-Ab-2Anti-Canine F10 monoclonal antibodyCanine
GM-Tg-bovg-T84631-Ab-1/ GM-Tg-bovg-T84631-Ab-2Anti-Bovine F10 monoclonal antibodyBovine
GM-Tg-equg-T84631-Ab-1/ GM-Tg-equg-T84631-Ab-2Anti-Equine F10 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T84631-Ab-1/ GM-Tg-hg-T84631-Ab-2; GM-Tg-rg-T84631-Ab-1/ GM-Tg-rg-T84631-Ab-2;
GM-Tg-mg-T84631-Ab-1/ GM-Tg-mg-T84631-Ab-2; GM-Tg-cynog-T84631-Ab-1/ GM-Tg-cynog-T84631-Ab-2;
GM-Tg-felg-T84631-Ab-1/ GM-Tg-felg-T84631-Ab-2; GM-Tg-cang-T84631-Ab-1/ GM-Tg-cang-T84631-Ab-2;
GM-Tg-bovg-T84631-Ab-1/ GM-Tg-bovg-T84631-Ab-2; GM-Tg-equg-T84631-Ab-1/ GM-Tg-equg-T84631-Ab-2
Products NameAnti-F10 monoclonal antibody
Formatmab
Target NameF10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-F10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-177Pre-Made Emicizumab biosimilar, Bispecific mAb, Anti-F9;F10 Antibody: Anti-FIX/HEMB/P19/PTC/THPH8;FX/FXA therapeutic antibody
    Target AntigenProducts DevelopingMulti-species FA10/ F10/ FX VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAP000423Human F10 Adenovirus plasmid
    ORF Viral VectorvGMAP000423Human F10 Adenovirus particle
    ORF Viral VectorpGMLPm002072mouse F10 Lentivirus plasmid
    ORF Viral VectorvGMLPm002072mouse F10 Lentivirus particle


    Target information

    Target IDGM-T84631
    Target NameF10
    Gene ID2159,14058,29243,714132,280787,100067094
    Gene Symbol and SynonymsCf10,F10,FX,FXA
    Uniprot AccessionP00742,Q63207,P00743
    Uniprot Entry NameFA10_HUMAN,FA10_RAT,FA10_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000126218
    Target ClassificationN/A

    The target: F10, gene name: F10, also named as FX, FXA. This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.