Anti-CCN1/ CYR61/ GIG1 functional antibody

Anti-CCN1/ CYR61/ GIG1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CYR61/CCN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T85289-Ab-1/ GM-Tg-hg-T85289-Ab-2Anti-Human CYR61/CCN1 monoclonal antibodyHuman
GM-Tg-rg-T85289-Ab-1/ GM-Tg-rg-T85289-Ab-2Anti-Rat CYR61/CCN1 monoclonal antibodyRat
GM-Tg-mg-T85289-Ab-1/ GM-Tg-mg-T85289-Ab-2Anti-Mouse CYR61/CCN1 monoclonal antibodyMouse
GM-Tg-cynog-T85289-Ab-1/ GM-Tg-cynog-T85289-Ab-2Anti-Cynomolgus/ Rhesus macaque CYR61/CCN1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T85289-Ab-1/ GM-Tg-felg-T85289-Ab-2Anti-Feline CYR61/CCN1 monoclonal antibodyFeline
GM-Tg-cang-T85289-Ab-1/ GM-Tg-cang-T85289-Ab-2Anti-Canine CYR61/CCN1 monoclonal antibodyCanine
GM-Tg-bovg-T85289-Ab-1/ GM-Tg-bovg-T85289-Ab-2Anti-Bovine CYR61/CCN1 monoclonal antibodyBovine
GM-Tg-equg-T85289-Ab-1/ GM-Tg-equg-T85289-Ab-2Anti-Equine CYR61/CCN1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T85289-Ab-1/ GM-Tg-hg-T85289-Ab-2; GM-Tg-rg-T85289-Ab-1/ GM-Tg-rg-T85289-Ab-2;
GM-Tg-mg-T85289-Ab-1/ GM-Tg-mg-T85289-Ab-2; GM-Tg-cynog-T85289-Ab-1/ GM-Tg-cynog-T85289-Ab-2;
GM-Tg-felg-T85289-Ab-1/ GM-Tg-felg-T85289-Ab-2; GM-Tg-cang-T85289-Ab-1/ GM-Tg-cang-T85289-Ab-2;
GM-Tg-bovg-T85289-Ab-1/ GM-Tg-bovg-T85289-Ab-2; GM-Tg-equg-T85289-Ab-1/ GM-Tg-equg-T85289-Ab-2
Products NameAnti-CYR61/CCN1 monoclonal antibody
Formatmab
Target NameCYR61
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CYR61 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T85289-Ag-1Recombinant multi-species CCN1/ CYR61/ GIG1 protein
    CytokineGM-Tg-g-T85289-Ag-1cysteine-rich, angiogenic inducer, 61 (CYR61) protein
    ORF Viral VectorvGMLP000491human CYR61 Lentivirus particle
    ORF Viral VectorpGMLP000491human CYR61 Lentivirus plasmid
    ORF Viral VectorvGMAP000008Human CYR61 Adenovirus particle
    ORF Viral VectorpGMAP000008Human CYR61 Adenovirus plasmid
    ORF Viral VectorpGMAD000547Norway rat Ccn1 Adenovirus plasmid
    ORF Viral VectorvGMAD000547Norway rat Ccn1 Adenovirus particle
    ORF Viral VectorpGMLPm002791mouse Cyr61 Lentivirus plasmid
    ORF Viral VectorvGMLPm002791mouse Cyr61 Lentivirus particle


    Target information

    Target IDGM-T85289
    Target NameCYR61
    Gene ID3491,16007,83476,714970,479967,101100068,508941,100064066
    Gene Symbol and SynonymsCCN1,CYR61,GIG1,IGFBP10
    Uniprot AccessionO00622,Q9ES72
    Uniprot Entry NameCCN1_HUMAN,CCN1_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryCytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000142871
    Target ClassificationTumor-associated antigen (TAA)

    The target: CYR61, gene name: CCN1, also named as CYR61, GIG1, IGFBP10. The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.