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Anti-S22AC/ URAT1/ SLC22A12 monoclonal antibody
Anti-S22AC/ URAT1/ SLC22A12 antibody for FACS & in-vivo assay
Go to URAT1/SLC22A12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T86057-Ab-1/ GM-Tg-hg-T86057-Ab-2 | Anti-Human URAT1/SLC22A12 monoclonal antibody | Human |
| GM-Tg-rg-T86057-Ab-1/ GM-Tg-rg-T86057-Ab-2 | Anti-Rat URAT1/SLC22A12 monoclonal antibody | Rat |
| GM-Tg-mg-T86057-Ab-1/ GM-Tg-mg-T86057-Ab-2 | Anti-Mouse URAT1/SLC22A12 monoclonal antibody | Mouse |
| GM-Tg-cynog-T86057-Ab-1/ GM-Tg-cynog-T86057-Ab-2 | Anti-Cynomolgus/ Rhesus macaque URAT1/SLC22A12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T86057-Ab-1/ GM-Tg-felg-T86057-Ab-2 | Anti-Feline URAT1/SLC22A12 monoclonal antibody | Feline |
| GM-Tg-cang-T86057-Ab-1/ GM-Tg-cang-T86057-Ab-2 | Anti-Canine URAT1/SLC22A12 monoclonal antibody | Canine |
| GM-Tg-bovg-T86057-Ab-1/ GM-Tg-bovg-T86057-Ab-2 | Anti-Bovine URAT1/SLC22A12 monoclonal antibody | Bovine |
| GM-Tg-equg-T86057-Ab-1/ GM-Tg-equg-T86057-Ab-2 | Anti-Equine URAT1/SLC22A12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T86057-Ab-1/ GM-Tg-hg-T86057-Ab-2; GM-Tg-rg-T86057-Ab-1/ GM-Tg-rg-T86057-Ab-2; GM-Tg-mg-T86057-Ab-1/ GM-Tg-mg-T86057-Ab-2; GM-Tg-cynog-T86057-Ab-1/ GM-Tg-cynog-T86057-Ab-2; GM-Tg-felg-T86057-Ab-1/ GM-Tg-felg-T86057-Ab-2; GM-Tg-cang-T86057-Ab-1/ GM-Tg-cang-T86057-Ab-2; GM-Tg-bovg-T86057-Ab-1/ GM-Tg-bovg-T86057-Ab-2; GM-Tg-equg-T86057-Ab-1/ GM-Tg-equg-T86057-Ab-2 |
| Products Name | Anti-URAT1/SLC22A12 monoclonal antibody |
| Format | mab |
| Target Name | URAT1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-URAT1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S22AC/ URAT1/ SLC22A12 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000029 | human SLC22A12 Lentivirus particle |
| ORF Viral Vector | pGMLV000029 | human SLC22A12 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005349 | mouse Slc22a12 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005349 | mouse Slc22a12 Lentivirus particle |
Target information
| Target ID | GM-T86057 |
| Target Name | URAT1 |
| Gene ID | 116085,365398,717530,483761,101100592,100055832 |
| Gene Symbol and Synonyms | hURAT1,OAT4L,RST,SLC22A12,Slc22al2,UAT,URAT1 |
| Uniprot Accession | Q96S37,Q3ZAV1 |
| Uniprot Entry Name | S22AC_HUMAN,S22AC_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000197891 |
| Target Classification | N/A |
The target: URAT1, gene name: SLC22A12, also named as OAT4L, RST, URAT1. The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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