Anti-GRIA2/ pGluA2/ GLUR2 monoclonal antibody

Anti-GRIA2/ pGluA2/ GLUR2 antibody for FACS & in-vivo assay

Target products collectionGo to pGluA2/GRIA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T90897-Ab-1/ GM-Tg-hg-T90897-Ab-2Anti-Human pGluA2/GRIA2 monoclonal antibodyHuman
GM-Tg-rg-T90897-Ab-1/ GM-Tg-rg-T90897-Ab-2Anti-Rat pGluA2/GRIA2 monoclonal antibodyRat
GM-Tg-mg-T90897-Ab-1/ GM-Tg-mg-T90897-Ab-2Anti-Mouse pGluA2/GRIA2 monoclonal antibodyMouse
GM-Tg-cynog-T90897-Ab-1/ GM-Tg-cynog-T90897-Ab-2Anti-Cynomolgus/ Rhesus macaque pGluA2/GRIA2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T90897-Ab-1/ GM-Tg-felg-T90897-Ab-2Anti-Feline pGluA2/GRIA2 monoclonal antibodyFeline
GM-Tg-cang-T90897-Ab-1/ GM-Tg-cang-T90897-Ab-2Anti-Canine pGluA2/GRIA2 monoclonal antibodyCanine
GM-Tg-bovg-T90897-Ab-1/ GM-Tg-bovg-T90897-Ab-2Anti-Bovine pGluA2/GRIA2 monoclonal antibodyBovine
GM-Tg-equg-T90897-Ab-1/ GM-Tg-equg-T90897-Ab-2Anti-Equine pGluA2/GRIA2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T90897-Ab-1/ GM-Tg-hg-T90897-Ab-2; GM-Tg-rg-T90897-Ab-1/ GM-Tg-rg-T90897-Ab-2;
GM-Tg-mg-T90897-Ab-1/ GM-Tg-mg-T90897-Ab-2; GM-Tg-cynog-T90897-Ab-1/ GM-Tg-cynog-T90897-Ab-2;
GM-Tg-felg-T90897-Ab-1/ GM-Tg-felg-T90897-Ab-2; GM-Tg-cang-T90897-Ab-1/ GM-Tg-cang-T90897-Ab-2;
GM-Tg-bovg-T90897-Ab-1/ GM-Tg-bovg-T90897-Ab-2; GM-Tg-equg-T90897-Ab-1/ GM-Tg-equg-T90897-Ab-2
Products NameAnti-pGluA2/GRIA2 monoclonal antibody
Formatmab
Target NamepGluA2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-pGluA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GRIA2/ pGluA2/ GLUR2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm004752mouse Gria2 Lentivirus plasmid
    ORF Viral VectorvGMLPm004752mouse Gria2 Lentivirus particle


    Target information

    Target IDGM-T90897
    Target NamepGluA2
    Gene ID2891,14800,29627,574344,482667,101088234,614283,100069331
    Gene Symbol and SynonymsGluA2,gluR-2,gluR-B,GluR-K2,GLUR2,GLURB,GRIA2,HBGR2,NEDLIB
    Uniprot AccessionP42262,P19491
    Uniprot Entry NameGRIA2_HUMAN,GRIA2_RAT
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000120251
    Target ClassificationN/A

    The target: pGluA2, gene name: GRIA2, also named as GLUR2, GLURB, GluA2, GluR-K2, HBGR2. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.