Anti-GRIA2/ pGluA2/ GLUR2 monoclonal antibody
Anti-GRIA2/ pGluA2/ GLUR2 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T90897-Ab-1/ GM-Tg-hg-T90897-Ab-2 | Anti-Human pGluA2/GRIA2 monoclonal antibody | Human |
GM-Tg-rg-T90897-Ab-1/ GM-Tg-rg-T90897-Ab-2 | Anti-Rat pGluA2/GRIA2 monoclonal antibody | Rat |
GM-Tg-mg-T90897-Ab-1/ GM-Tg-mg-T90897-Ab-2 | Anti-Mouse pGluA2/GRIA2 monoclonal antibody | Mouse |
GM-Tg-cynog-T90897-Ab-1/ GM-Tg-cynog-T90897-Ab-2 | Anti-Cynomolgus/ Rhesus macaque pGluA2/GRIA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T90897-Ab-1/ GM-Tg-felg-T90897-Ab-2 | Anti-Feline pGluA2/GRIA2 monoclonal antibody | Feline |
GM-Tg-cang-T90897-Ab-1/ GM-Tg-cang-T90897-Ab-2 | Anti-Canine pGluA2/GRIA2 monoclonal antibody | Canine |
GM-Tg-bovg-T90897-Ab-1/ GM-Tg-bovg-T90897-Ab-2 | Anti-Bovine pGluA2/GRIA2 monoclonal antibody | Bovine |
GM-Tg-equg-T90897-Ab-1/ GM-Tg-equg-T90897-Ab-2 | Anti-Equine pGluA2/GRIA2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T90897-Ab-1/ GM-Tg-hg-T90897-Ab-2; GM-Tg-rg-T90897-Ab-1/ GM-Tg-rg-T90897-Ab-2; GM-Tg-mg-T90897-Ab-1/ GM-Tg-mg-T90897-Ab-2; GM-Tg-cynog-T90897-Ab-1/ GM-Tg-cynog-T90897-Ab-2; GM-Tg-felg-T90897-Ab-1/ GM-Tg-felg-T90897-Ab-2; GM-Tg-cang-T90897-Ab-1/ GM-Tg-cang-T90897-Ab-2; GM-Tg-bovg-T90897-Ab-1/ GM-Tg-bovg-T90897-Ab-2; GM-Tg-equg-T90897-Ab-1/ GM-Tg-equg-T90897-Ab-2 |
Products Name | Anti-pGluA2/GRIA2 monoclonal antibody |
Format | mab |
Target Name | pGluA2 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-pGluA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species GRIA2/ pGluA2/ GLUR2 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLPm004752 | mouse Gria2 Lentivirus plasmid |
ORF Viral Vector | vGMLPm004752 | mouse Gria2 Lentivirus particle |
Target information
Target ID | GM-T90897 |
Target Name | pGluA2 |
Gene ID | 2891,14800,29627,574344,482667,101088234,614283,100069331 |
Gene Symbol and Synonyms | GluA2,gluR-2,gluR-B,GluR-K2,GLUR2,GLURB,GRIA2,HBGR2,NEDLIB |
Uniprot Accession | P42262,P19491 |
Uniprot Entry Name | GRIA2_HUMAN,GRIA2_RAT |
Protein Sub-location | Transmembrane Protein |
Category | |
Disease | N/A |
Gene Ensembl | ENSG00000120251 |
Target Classification | N/A |
The target: pGluA2, gene name: GRIA2, also named as GLUR2, GLURB, GluA2, GluR-K2, HBGR2. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.