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Anti-FGFR3/ ACH/ CD333 monoclonal antibody
Anti-FGFR3/ ACH/ CD333 antibody for FACS & in-vivo assay
Go to FGFR3/FGFR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T91331-Ab-1/ GM-Tg-hg-T91331-Ab-2 | Anti-Human FGFR3 monoclonal antibody | Human |
| GM-Tg-rg-T91331-Ab-1/ GM-Tg-rg-T91331-Ab-2 | Anti-Rat FGFR3 monoclonal antibody | Rat |
| GM-Tg-mg-T91331-Ab-1/ GM-Tg-mg-T91331-Ab-2 | Anti-Mouse FGFR3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T91331-Ab-1/ GM-Tg-cynog-T91331-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FGFR3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T91331-Ab-1/ GM-Tg-felg-T91331-Ab-2 | Anti-Feline FGFR3 monoclonal antibody | Feline |
| GM-Tg-cang-T91331-Ab-1/ GM-Tg-cang-T91331-Ab-2 | Anti-Canine FGFR3 monoclonal antibody | Canine |
| GM-Tg-bovg-T91331-Ab-1/ GM-Tg-bovg-T91331-Ab-2 | Anti-Bovine FGFR3 monoclonal antibody | Bovine |
| GM-Tg-equg-T91331-Ab-1/ GM-Tg-equg-T91331-Ab-2 | Anti-Equine FGFR3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T91331-Ab-1/ GM-Tg-hg-T91331-Ab-2; GM-Tg-rg-T91331-Ab-1/ GM-Tg-rg-T91331-Ab-2; GM-Tg-mg-T91331-Ab-1/ GM-Tg-mg-T91331-Ab-2; GM-Tg-cynog-T91331-Ab-1/ GM-Tg-cynog-T91331-Ab-2; GM-Tg-felg-T91331-Ab-1/ GM-Tg-felg-T91331-Ab-2; GM-Tg-cang-T91331-Ab-1/ GM-Tg-cang-T91331-Ab-2; GM-Tg-bovg-T91331-Ab-1/ GM-Tg-bovg-T91331-Ab-2; GM-Tg-equg-T91331-Ab-1/ GM-Tg-equg-T91331-Ab-2 |
| Products Name | Anti-FGFR3 monoclonal antibody |
| Format | mab |
| Target Name | FGFR3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FGFR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-626 | Pre-Made Vofatamab biosimilar, Whole mAb, Anti-FGFR3 Antibody: Anti-ACH/CEK2/JTK4/CD333/HSFGFR3EX therapeutic antibody |
| Target Antigen | Products Developing | Multi-species FGFR3/ ACH/ CD333 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T91331-Ag-1 | fibroblast growth factor receptor 3 (FGFR3) protein |
| ORF Viral Vector | pGMLP001642 | human FGFR3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001642 | human FGFR3 Lentivirus particle |
Target information
| Target ID | GM-T91331 |
| Target Name | FGFR3 |
| Gene ID | 2261,14184,84489,712829,488808,100141386,281769,100034114 |
| Gene Symbol and Synonyms | ACH,CD333,CEK2,Fgfr-3,FGFR3,Flg-2,FR3,HBGFR,HSFGFR3EX,JTK4,Mfr3,sam3 |
| Uniprot Accession | P22607 |
| Uniprot Entry Name | FGFR3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Non-Small Cell Lung Cancer, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000068078 |
| Target Classification | Kinase |
The target: FGFR3, gene name: FGFR3, also named as ACH, CD333, CEK2, HSFGFR3EX, JTK4. This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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