Anti-SIRT3 monoclonal antibody

Pre-made anti-SIRT3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to SIRT3/SIRT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T91959-Ab-1/ GM-Tg-hg-T91959-Ab-2Anti-Human SIRT3 monoclonal antibodyHuman
GM-Tg-rg-T91959-Ab-1/ GM-Tg-rg-T91959-Ab-2Anti-Rat SIRT3 monoclonal antibodyRat
GM-Tg-mg-T91959-Ab-1/ GM-Tg-mg-T91959-Ab-2Anti-Mouse SIRT3 monoclonal antibodyMouse
GM-Tg-cynog-T91959-Ab-1/ GM-Tg-cynog-T91959-Ab-2Anti-Cynomolgus/ Rhesus macaque SIRT3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T91959-Ab-1/ GM-Tg-felg-T91959-Ab-2Anti-Feline SIRT3 monoclonal antibodyFeline
GM-Tg-cang-T91959-Ab-1/ GM-Tg-cang-T91959-Ab-2Anti-Canine SIRT3 monoclonal antibodyCanine
GM-Tg-bovg-T91959-Ab-1/ GM-Tg-bovg-T91959-Ab-2Anti-Bovine SIRT3 monoclonal antibodyBovine
GM-Tg-equg-T91959-Ab-1/ GM-Tg-equg-T91959-Ab-2Anti-Equine SIRT3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T91959-Ab-1/ GM-Tg-hg-T91959-Ab-2; GM-Tg-rg-T91959-Ab-1/ GM-Tg-rg-T91959-Ab-2;
GM-Tg-mg-T91959-Ab-1/ GM-Tg-mg-T91959-Ab-2; GM-Tg-cynog-T91959-Ab-1/ GM-Tg-cynog-T91959-Ab-2;
GM-Tg-felg-T91959-Ab-1/ GM-Tg-felg-T91959-Ab-2; GM-Tg-cang-T91959-Ab-1/ GM-Tg-cang-T91959-Ab-2;
GM-Tg-bovg-T91959-Ab-1/ GM-Tg-bovg-T91959-Ab-2; GM-Tg-equg-T91959-Ab-1/ GM-Tg-equg-T91959-Ab-2
Products NameAnti-SIRT3 monoclonal antibody
Formatmab
Target NameSIRT3
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-SIRT3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T91959-Ag-1Recombinant multi-species SIR3/ SIRT3/ SIR2L3 protein
    ORF Viral VectorvGMAD000249human SIRT3 Adenovirus particle
    ORF Viral VectorvGMAD000464human SIRT3 Adenovirus particle
    ORF Viral VectorpGMAD000249human SIRT3 Adenovirus plasmid
    ORF Viral VectorpGMLP002811human SIRT3 Lentivirus plasmid
    ORF Viral VectorpGMAD000464human SIRT3 Adenovirus plasmid
    ORF Viral VectorvGMLP002811human SIRT3 Lentivirus particle
    ORF Viral VectorpGMLV000371mouse Sirt3 Lentivirus plasmid
    ORF Viral VectorpGMLV000395mouse Sirt3 Lentivirus plasmid
    ORF Viral VectorpGMLV000826house mouse Sirt3 Lentivirus plasmid
    ORF Viral VectorpGMAD000084mouse Sirt3 Adenovirus plasmid
    ORF Viral VectorpGMAD000097cattle SIRT3 Adenovirus plasmid
    ORF Viral VectorpGMAAV000011rat Sirt3 AAV plasmid
    ORF Viral VectorpGMAAV000256house mouse Sirt3 AAV plasmid
    ORF Viral VectorpGMAAV000316house mouse Sirt3 AAV plasmid
    ORF Viral VectorpGMLPm001256mouse Sirt3 Lentivirus plasmid
    ORF Viral VectorvGMLV000371mouse Sirt3 Lentivirus particle
    ORF Viral VectorvGMLV000395mouse Sirt3 Lentivirus particle
    ORF Viral VectorvGMLV000826house mouse Sirt3 Lentivirus particle
    ORF Viral VectorvGMAD000084mouse Sirt3 Adenovirus particle
    ORF Viral VectorvGMAD000097cattle SIRT3 Adenovirus particle
    ORF Viral VectorvGMAAV000011rat Sirt3 AAV particle
    ORF Viral VectorvGMAAV000256house mouse Sirt3 AAV particle
    ORF Viral VectorvGMAAV000316house mouse Sirt3 AAV particle
    ORF Viral VectorvGMLPm001256mouse Sirt3 Lentivirus particle


    Target information

    Target IDGM-T91959
    Target NameSIRT3
    Gene ID23410,64384,293615,720737,475933,101087609,614027,100054908
    Gene Symbol and Synonyms2310003L23Rik,SIR2L3,SIRT3
    Uniprot AccessionQ9NTG7
    Uniprot Entry NameSIR3_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000142082
    Target ClassificationN/A

    The target: SIRT3, gene name: SIRT3, also named as SIR2L3. SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.