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Anti-AA1R/ ADORA1/ RDC7 monoclonal antibody
Anti-AA1R/ ADORA1/ RDC7 antibody for FACS & in-vivo assay
Go to ADORA1/ADORA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92072-Ab-1/ GM-Tg-hg-T92072-Ab-2 | Anti-Human ADORA1 monoclonal antibody | Human |
| GM-Tg-rg-T92072-Ab-1/ GM-Tg-rg-T92072-Ab-2 | Anti-Rat ADORA1 monoclonal antibody | Rat |
| GM-Tg-mg-T92072-Ab-1/ GM-Tg-mg-T92072-Ab-2 | Anti-Mouse ADORA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T92072-Ab-1/ GM-Tg-cynog-T92072-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ADORA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92072-Ab-1/ GM-Tg-felg-T92072-Ab-2 | Anti-Feline ADORA1 monoclonal antibody | Feline |
| GM-Tg-cang-T92072-Ab-1/ GM-Tg-cang-T92072-Ab-2 | Anti-Canine ADORA1 monoclonal antibody | Canine |
| GM-Tg-bovg-T92072-Ab-1/ GM-Tg-bovg-T92072-Ab-2 | Anti-Bovine ADORA1 monoclonal antibody | Bovine |
| GM-Tg-equg-T92072-Ab-1/ GM-Tg-equg-T92072-Ab-2 | Anti-Equine ADORA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92072-Ab-1/ GM-Tg-hg-T92072-Ab-2; GM-Tg-rg-T92072-Ab-1/ GM-Tg-rg-T92072-Ab-2; GM-Tg-mg-T92072-Ab-1/ GM-Tg-mg-T92072-Ab-2; GM-Tg-cynog-T92072-Ab-1/ GM-Tg-cynog-T92072-Ab-2; GM-Tg-felg-T92072-Ab-1/ GM-Tg-felg-T92072-Ab-2; GM-Tg-cang-T92072-Ab-1/ GM-Tg-cang-T92072-Ab-2; GM-Tg-bovg-T92072-Ab-1/ GM-Tg-bovg-T92072-Ab-2; GM-Tg-equg-T92072-Ab-1/ GM-Tg-equg-T92072-Ab-2 |
| Products Name | Anti-ADORA1 monoclonal antibody |
| Format | mab |
| Target Name | ADORA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ADORA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AA1R/ ADORA1/ RDC7 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP004056 | human ADORA1 Lentivirus particle |
| ORF Viral Vector | vGMLP002707 | human ADORA1 Lentivirus particle |
| ORF Viral Vector | pGMLP004056 | human ADORA1 Lentivirus plasmid |
| ORF Viral Vector | pGMLP002707 | human ADORA1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000927 | mouse Adora1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000927 | mouse Adora1 Lentivirus particle |
Target information
| Target ID | GM-T92072 |
| Target Name | ADORA1 |
| Gene ID | 134,11539,29290,703638,403961,101100536,282133,100052496 |
| Gene Symbol and Synonyms | A1-AR,A1AR,A1R,AA1R,ADORA1,ARA1,RDC7,Ri |
| Uniprot Accession | P30542,P25099,P11616,P28190 |
| Uniprot Entry Name | AA1R_HUMAN,AA1R_RAT,AA1R_CANLF,AA1R_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000163485 |
| Target Classification | N/A |
The target: ADORA1, gene name: ADORA1, also named as RDC7. The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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