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Anti-PSN1/ PSEN1/ ACNINV3 monoclonal antibody
Anti-PSN1/ PSEN1/ ACNINV3 antibody for FACS & in-vivo assay
Go to PSEN1/PSEN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T93105-Ab-1/ GM-Tg-hg-T93105-Ab-2 | Anti-Human PSEN1 monoclonal antibody | Human |
| GM-Tg-rg-T93105-Ab-1/ GM-Tg-rg-T93105-Ab-2 | Anti-Rat PSEN1 monoclonal antibody | Rat |
| GM-Tg-mg-T93105-Ab-1/ GM-Tg-mg-T93105-Ab-2 | Anti-Mouse PSEN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T93105-Ab-1/ GM-Tg-cynog-T93105-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PSEN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T93105-Ab-1/ GM-Tg-felg-T93105-Ab-2 | Anti-Feline PSEN1 monoclonal antibody | Feline |
| GM-Tg-cang-T93105-Ab-1/ GM-Tg-cang-T93105-Ab-2 | Anti-Canine PSEN1 monoclonal antibody | Canine |
| GM-Tg-bovg-T93105-Ab-1/ GM-Tg-bovg-T93105-Ab-2 | Anti-Bovine PSEN1 monoclonal antibody | Bovine |
| GM-Tg-equg-T93105-Ab-1/ GM-Tg-equg-T93105-Ab-2 | Anti-Equine PSEN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T93105-Ab-1/ GM-Tg-hg-T93105-Ab-2; GM-Tg-rg-T93105-Ab-1/ GM-Tg-rg-T93105-Ab-2; GM-Tg-mg-T93105-Ab-1/ GM-Tg-mg-T93105-Ab-2; GM-Tg-cynog-T93105-Ab-1/ GM-Tg-cynog-T93105-Ab-2; GM-Tg-felg-T93105-Ab-1/ GM-Tg-felg-T93105-Ab-2; GM-Tg-cang-T93105-Ab-1/ GM-Tg-cang-T93105-Ab-2; GM-Tg-bovg-T93105-Ab-1/ GM-Tg-bovg-T93105-Ab-2; GM-Tg-equg-T93105-Ab-1/ GM-Tg-equg-T93105-Ab-2 |
| Products Name | Anti-PSEN1 monoclonal antibody |
| Format | mab |
| Target Name | PSEN1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PSEN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PSN1/ PSEN1/ ACNINV3 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000462 | human PSEN1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000766 | human PSEN1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000462 | human PSEN1 Lentivirus particle |
| ORF Viral Vector | vGMLV000766 | human PSEN1 Lentivirus particle |
Target information
| Target ID | GM-T93105 |
| Target Name | PSEN1 |
| Gene ID | 5663,19164,29192,696274,403408,101087239,282705,100050164 |
| Gene Symbol and Synonyms | ACNINV3,AD3,Ad3h,FAD,PS-1,PS1,PSEN1,PSNL1,S182 |
| Uniprot Accession | P49768,P97887,Q6RH31,Q9XT97 |
| Uniprot Entry Name | PSN1_HUMAN,PSN1_RAT,PSN1_CANLF,PSN1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000080815 |
| Target Classification | N/A |
The target: PSEN1, gene name: PSEN1, also named as ACNINV3, AD3, FAD, PS-1, PS1, S182. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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