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Anti-GLSK/ GLS/ AAD20 functional antibody
Anti-GLSK/ GLS/ AAD20 functional antibody for cell culture, ELISA & in-vivo assay
Go to GLS/GLS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-TA039-Ab-1/ GM-Tg-hg-TA039-Ab-2 | Anti-Human GLS monoclonal antibody | Human |
| GM-Tg-rg-TA039-Ab-1/ GM-Tg-rg-TA039-Ab-2 | Anti-Rat GLS monoclonal antibody | Rat |
| GM-Tg-mg-TA039-Ab-1/ GM-Tg-mg-TA039-Ab-2 | Anti-Mouse GLS monoclonal antibody | Mouse |
| GM-Tg-cynog-TA039-Ab-1/ GM-Tg-cynog-TA039-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GLS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-TA039-Ab-1/ GM-Tg-felg-TA039-Ab-2 | Anti-Feline GLS monoclonal antibody | Feline |
| GM-Tg-cang-TA039-Ab-1/ GM-Tg-cang-TA039-Ab-2 | Anti-Canine GLS monoclonal antibody | Canine |
| GM-Tg-bovg-TA039-Ab-1/ GM-Tg-bovg-TA039-Ab-2 | Anti-Bovine GLS monoclonal antibody | Bovine |
| GM-Tg-equg-TA039-Ab-1/ GM-Tg-equg-TA039-Ab-2 | Anti-Equine GLS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-TA039-Ab-1/ GM-Tg-hg-TA039-Ab-2; GM-Tg-rg-TA039-Ab-1/ GM-Tg-rg-TA039-Ab-2; GM-Tg-mg-TA039-Ab-1/ GM-Tg-mg-TA039-Ab-2; GM-Tg-cynog-TA039-Ab-1/ GM-Tg-cynog-TA039-Ab-2; GM-Tg-felg-TA039-Ab-1/ GM-Tg-felg-TA039-Ab-2; GM-Tg-cang-TA039-Ab-1/ GM-Tg-cang-TA039-Ab-2; GM-Tg-bovg-TA039-Ab-1/ GM-Tg-bovg-TA039-Ab-2; GM-Tg-equg-TA039-Ab-1/ GM-Tg-equg-TA039-Ab-2 |
| Products Name | Anti-GLS monoclonal antibody |
| Format | mab |
| Target Name | GLS |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GLS benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-TA039-Ag-1 | Recombinant multi-species GLSK/ GLS/ AAD20 protein |
| ORF Viral Vector | vGMLV000116 | human GLS Lentivirus particle |
| ORF Viral Vector | pGMLV000116 | human GLS Lentivirus plasmid |
Target information
| Target ID | GM-TA039 |
| Target Name | GLS |
| Gene ID | 2744,14660,24398,693520,488448,101080395,525335,100069617 |
| Gene Symbol and Synonyms | 6330442B14,AAD20,B230365M23Rik,CASGID,DEE71,EIEE71,GAC,GAM,GDPAG,GLS,GLS1,Glut,KGA,RATGLUT |
| Uniprot Accession | O94925,P13264 |
| Uniprot Entry Name | GLSK_HUMAN,GLSK_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000115419 |
| Target Classification | N/A |
The target: GLS, gene name: GLS, also named as AAD20, GAC, GAM1, KGA, GLS. This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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