Bovine PA antibody and antigen (recombinant protein)

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Diagnostic anti-Bovine PA antibodies pairs and antigen for animal health (animal Bovines/Cattle liver disease, inflammation, or tissue death) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Size： 1mg | 10mg | 100mg

Product Description

Reference

Validation Data

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Target/Biomarker Information

Bovine Prothrombin Activation Fragment 1+2 (cPAF1+2) stands as a pivotal biochemical entity within the intricate tapestry of bovine hemostasis. Structurally, it emerges as a fragment resulting from the activation of prothrombin (Factor II) into thrombin (Factor IIa) during the coagulation cascade—a process choreographed by a cascade of coagulation factors and platelet interactions. This activation event serves as the foundation of blood clot formation, a process that underpins the hemostatic equilibrium in cattle.

Prothrombin, an unassuming precursor protein, circulates in the bovine bloodstream until it encounters vascular injury. When such an injury occurs, a meticulously orchestrated sequence of enzymatic reactions unfolds, culminating in the cleavage of prothrombin into two fragments: thrombin and cPAF1+2. Thrombin, the multifaceted enzyme generated through this process, assumes the central role in creating a stable blood clot. It catalyzes the conversion of soluble fibrinogen into insoluble fibrin strands, which provide the structural scaffold of a clot.

In contrast, cPAF1+2 does not actively participate in clot formation but plays a pivotal role as a marker of ongoing thrombin generation within the bovine hemostatic system. Its presence in circulation serves as a dynamic reflection of the equilibrium between prothrombin activation and thrombin regulation, offering insights into the coagulation status of cattle.

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