Bovine lactoferrin antibody and antigen (recombinant protein)

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Diagnostic anti-Bovine lactoferrin antibodies pairs and antigen for animal health (animal Bovines/Cattle Intestinal Health) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Target/Biomarker Information

Lactoferrin, a multifunctional protein of the transferrin family known for its strong iron-binding properties, plays a crucial role in the health and disease management of bovines or cattle. In cattle, lactoferrin is present in various secretions, including milk, colostrum, and saliva, and it serves several critical functions related to immune defense, iron metabolism, and anti-inflammatory activities. Its presence and concentration in bovine secretions have significant implications for both animal health and dairy product quality.

Immune Defense: Lactoferrin's role in the immune system is multifaceted. It exhibits potent antimicrobial properties against a wide range of pathogens, including bacteria, viruses, fungi, and parasites, primarily through its ability to sequester iron, which is essential for microbial growth. Additionally, lactoferrin can directly bind to bacteria and viruses, inhibiting their attachment to host cells and preventing infection. This makes lactoferrin an important component of the innate immune system in cattle, contributing to the animals' natural defenses against infectious diseases.

Anti-inflammatory Properties: Lactoferrin has been shown to possess anti-inflammatory properties, which are crucial in the context of bovine health. It can modulate the immune response, reducing the production of pro-inflammatory cytokines and mitigating the effects of excessive inflammation. This action helps protect tissues from damage during infections and inflammatory conditions, promoting more efficient healing and recovery processes.

Iron Metabolism: By tightly binding iron, lactoferrin regulates its availability in the body, supporting essential physiological processes while also limiting the growth of pathogenic microorganisms that require iron. This balance is vital for maintaining health and preventing diseases, particularly in the context of iron-sensitive infections.

Growth and Development: Lactoferrin is also involved in promoting growth and development in calves. Its presence in colostrum and milk supports the immature immune system of the newborn calf and contributes to gut health and development. The protein promotes the growth of beneficial intestinal flora and enhances the intestinal barrier function, which is essential for nutrient absorption and protection against pathogens.

Applications in Dairy Production: Beyond its biological roles, lactoferrin has applications in dairy production and animal husbandry. Due to its antimicrobial and anti-inflammatory properties, lactoferrin supplementation is explored for improving animal health, enhancing the quality of milk, and potentially reducing the need for antibiotics. Moreover, lactoferrin extracted from bovine milk is a valuable ingredient in infant formula, nutritional supplements, and health products, recognized for its protective and health-promoting properties.

In summary, lactoferrin is a critical protein in bovines with wide-ranging functions that support immune defense, modulate inflammation, regulate iron metabolism, and contribute to the growth and health of cattle. Its significance extends from fundamental biological roles in the animal to practical applications in dairy production and human nutrition, highlighting its multifunctional nature and the potential for continued research and application in veterinary medicine and dairy science.

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