Bovine pancreatic lipase antibody and antigen (recombinant protein)

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Diagnostic anti-Bovine pancreatic lipase antibodies pairs and antigen for animal health (animal Bovines/Cattle Pancreatitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product Description

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Validation Data

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Target/Biomarker Information

Pancreatic lipase is an enzyme produced by the pancreas in cattle, as in other mammals, and is essential for the digestion of dietary fats. The enzyme is secreted into the small intestine where it catalyzes the breakdown of triglycerides, which are fats, into monoglycerides and free fatty acids. These smaller molecules can then be absorbed by the intestinal cells.

Roles and Importance of Bovine Pancreatic Lipase:

Fat Digestion: Pancreatic lipase is the primary enzyme responsible for the digestion of long-chain triglycerides, the most common form of fats in the bovine diet.

Absorption: The products of lipase activity, mainly monoglycerides and free fatty acids, are then emulsified by bile salts (from the liver) in the small intestine to form micelles, which can be readily absorbed by the intestinal mucosa.

Energy Production: Fatty acids are a major source of energy for cattle, especially for high-producing animals like dairy cows. After absorption, these fatty acids can be metabolized to provide energy or can be re-esterified into triglycerides and stored in adipose tissue.

Milk Fat Synthesis: In dairy cattle, the absorbed fatty acids can also be incorporated into milk fat. The efficiency of lipase-mediated fat digestion, therefore, has a direct impact on the quality and fat content of the milk produced.

Clinical Implications and Applications:

Exocrine Pancreatic Insufficiency (EPI): In cases where the pancreas is unable to produce enough digestive enzymes, including lipase, cattle can suffer from EPI. This condition leads to malabsorption and maldigestion, particularly of fats, resulting in steatorrhea (fatty stools), weight loss, and deficiencies in fat-soluble vitamins.

Pancreatitis: While less common in cattle than in companion animals and humans, pancreatitis can lead to decreased production of pancreatic lipase, among other digestive enzymes, impairing fat digestion and causing systemic effects.

Diagnostics: Measurement of pancreatic lipase activity can be part of diagnosing pancreatic function and health. In other species, specific lipase assays are used to diagnose pancreatitis, but these are less commonly used in cattle.

Nutritional Management:

Dietary management in cattle is important to ensure that the fat content in the diet is appropriate for optimal digestion and absorption, which involves proper pancreatic lipase function.

In cases of EPI or other conditions affecting lipase production, dietary modifications, such as reducing fat intake or adding medium-chain triglycerides (which are more easily absorbed) to the diet, can be beneficial.

In summary, bovine pancreatic lipase is a vital digestive enzyme that plays a key role in the absorption and metabolism of dietary fats in cattle. It is essential for energy production, milk fat synthesis, and overall nutritional health. Understanding its function and managing related conditions are important aspects of veterinary care and nutritional management in bovine species.

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