Bovine proBNP antibody and antigen (recombinant protein)

Diagnostic anti-Bovine proBNP antibodies pairs and antigen for animal health (animal Bovines/Cattle intrinsic cardiac dysfunction) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-BOV-proBNP-Ag01Bovine proBNP$3090.00
GMP-BOV-proBNP-Ab01Anti-Bovine proBNP mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-proBNP-Ab02Anti-Bovine proBNP mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-proBNP-Ab03Anti-Bovine proBNP human monoclonal antibody (mAb)$3090.00
GMP-BOV-proBNP-Ab04Anti-Bovine proBNP human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-BOV-proBNP-Ag01
Product NameBovine proBNP
Target/BiomarkerBovine proBNP
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Bovine proBNP antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in proBNP level test of animal Bovines/Cattle with intrinsic cardiac dysfunction.
TagHis
Reconized/Reactive SpecicsBovine proBNP
Product descriptionRecombinant Bovine proBNP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-proBNP-Ab01,GMP-BOV-proBNP-Ab02
Target/BiomarkerBovine proBNP
Product NameAnti-Bovine proBNP mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Bovine proBNP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine proBNP antibodies in Bovine proBNP level test of animal Bovines/Cattle with intrinsic cardiac dysfunction.
Product descriptionAnti-Bovine proBNP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine proBNP antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-proBNP-Ab03,GMP-BOV-proBNP-Ab04
Target/BiomarkerBovine proBNP
Product NameAnti-Bovine proBNP human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Bovine proBNP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine proBNP antibodies in Bovine proBNP level test of animal Bovines/Cattle with intrinsic cardiac dysfunction.
Product descriptionAnti-Bovine proBNP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is a circulating biomarker that is  derived from the precursor molecule proBNP, which is synthesized in the cardiac ventricles of animals, including bovines/cattle. ProBNP consists of a 108-amino acid polypeptide that is cleaved into two distinct fragments, N-terminal proBNP (NT-proBNP) and active brain natriuretic peptide (BNP). NT-proBNP is released into the bloodstream in response to cardiac stress or injury, as well as mechanical and neurohormonal stimuli. It is a marker of cardiac strain and dysfunction, reflecting increased wall tension in the ventricles.

    The concentration of NT-proBNP in the bloodstream reflects the degree of cardiac impairment, making it a valuable biomarker for monitoring cardiovascular health and predicting adverse events in bovines/cattle. NT-proBNP achieves its vasodilatory and natriuretic effects through the interaction of natriuretic peptide receptor A (NPRA) and NPRA-associated guanylate cyclase domains. The resulting increase in cyclic guanosine monophosphate (cGMP) leads to the relaxation of vascular smooth muscles and increased salt and water excretion.

    NT-proBNP has a relatively long half-life of approximately 1-2 hours, making it a useful diagnostic tool as it remains elevated for more extended periods than the active hormone BNP. It can be measured in serum or plasma using various immunoassays, including enzyme-linked immunosorbent assay (ELISA) and chemiluminescent immunoassay (CLIA). NT-proBNP levels are age and breed-specific, with healthy animals exhibiting lower levels than those affected by cardiovascular disease.



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