Canine ApoE antibody and antigen (recombinant protein)

Diagnostic anti-Canine ApoE antibodies pairs and antigen for animal health (animal Dog/Canine Cardiovascular Disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-ApoE-Ag01Canine ApoE$3090.00
GMP-CAN-ApoE-Ab01Anti-Canine ApoE mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-ApoE-Ab02Anti-Canine ApoE mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-ApoE-Ab03Anti-Canine ApoE human monoclonal antibody (mAb)$3090.00
GMP-CAN-ApoE-Ab04Anti-Canine ApoE human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-ApoE-Ag01
Product NameCanine ApoE
Target/BiomarkerCanine ApoE
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine ApoE antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ApoE level test of animal Dog/Canine with Cardiovascular Disease.
TagHis
Reconized/Reactive SpecicsCanine ApoE
Product descriptionRecombinant Canine ApoE protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-ApoE-Ab01,GMP-CAN-ApoE-Ab02
Target/BiomarkerCanine ApoE
Product NameAnti-Canine ApoE mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine ApoE antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine ApoE antibodies in Canine ApoE level test of animal Dog/Canine with Cardiovascular Disease.
Product descriptionAnti-Canine ApoE mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine ApoE antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-ApoE-Ab03,GMP-CAN-ApoE-Ab04
Target/BiomarkerCanine ApoE
Product NameAnti-Canine ApoE human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine ApoE antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine ApoE antibodies in Canine ApoE level test of animal Dog/Canine with Cardiovascular Disease.
Product descriptionAnti-Canine ApoE mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine Apolipoprotein E, more commonly referred to as Canine ApoE, is a multifaceted protein that holds a central position in the intricate landscape of canine physiology. Synthesized predominantly in the liver and brain of domestic dogs (Canis lupus familiaris), this glycoprotein possesses a distinctive structure characterized by carbohydrates attached to its polypeptide chain. As a distinguished member of the apolipoprotein family, Canine ApoE plays a pivotal role in regulating lipid metabolism, with a particular emphasis on cholesterol management within the canine body.

    The significance of Canine ApoE becomes most apparent in its association with high-density lipoproteins (HDL), widely recognized as "good cholesterol." HDL particles, responsible for transporting cholesterol and lipids in the bloodstream, rely significantly on Canine ApoE for their structural integrity and functionality. This biomarker is an indispensable component of HDLs, contributing not only to their structural integrity but also to their dynamic role in the reverse cholesterol transport pathway.

    The orchestration of cholesterol transport begins when Canine ApoE binds to lipids, effectively transforming nascent HDL particles into active carriers of excess cholesterol. These HDLs venture into peripheral tissues, retrieving surplus cholesterol and lipids, and then embark on a journey back to the liver. In the liver, cholesterol undergoes metabolism and eventual excretion, thus ensuring the maintenance of healthy cholesterol levels within the canine body.



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