Canine CBL antibody and antigen (recombinant protein)

Diagnostic anti-Canine CBL antibodies pairs and antigen for animal health (animal Dog/Canine ectopia lentis, learning difficulties and skeletal abnormalities) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-CBL-Ag01Canine CBL$3090.00
GMP-CAN-CBL-Ab01Anti-Canine CBL mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-CBL-Ab02Anti-Canine CBL mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-CBL-Ab03Anti-Canine CBL human monoclonal antibody (mAb)$3090.00
GMP-CAN-CBL-Ab04Anti-Canine CBL human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-CBL-Ag01
Product NameCanine CBL
Target/BiomarkerCanine CBL
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine CBL antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in CBL level test of animal Dog/Canine with ectopia lentis, learning difficulties and skeletal abnormalities.
TagHis
Reconized/Reactive SpecicsCanine CBL
Product descriptionRecombinant Canine CBL protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-CBL-Ab01,GMP-CAN-CBL-Ab02
Target/BiomarkerCanine CBL
Product NameAnti-Canine CBL mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine CBL antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine CBL antibodies in Canine CBL level test of animal Dog/Canine with ectopia lentis, learning difficulties and skeletal abnormalities.
Product descriptionAnti-Canine CBL mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine CBL antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-CBL-Ab03,GMP-CAN-CBL-Ab04
Target/BiomarkerCanine CBL
Product NameAnti-Canine CBL human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine CBL antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine CBL antibodies in Canine CBL level test of animal Dog/Canine with ectopia lentis, learning difficulties and skeletal abnormalities.
Product descriptionAnti-Canine CBL mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Cobalamin, or Vitamin B12, is a veritable biochemical marvel within the canine (dog) population. This water-soluble vitamin, represented by the biomarker CBL, serves as a linchpin in countless metabolic pathways critical to canine health and vitality.

    At its heart, Vitamin B12 boasts a complex molecular structure, characterized by a central cobalt atom. This cobalt atom is the epicenter of Vitamin B12's biological activity, essential for its role as a cofactor in enzymatic reactions vital to a dog's well-being.

    One of Vitamin B12's pivotal roles is in the conversion of methylmalonyl-CoA to succinyl-CoA, a process catalyzed by the enzyme methylmalonyl-CoA mutase. This reaction has far-reaching implications, as it contributes to the metabolism of fatty acids and amino acids. Additionally, Vitamin B12 participates in the conversion of homocysteine to methionine, a reaction catalyzed by methionine synthase. Methionine is a fundamental amino acid, and its synthesis is indispensable for protein production and overall cellular function.

    Beyond its involvement in amino acid and fatty acid metabolism, Vitamin B12 holds a critical place in DNA synthesis. Dogs rely on Vitamin B12 for the production of thymidine, one of the four nucleotide building blocks of DNA. This role is foundational for growth, tissue repair, and overall canine development.

    Vitamin B12's significance extends to the production of myelin, the insulating sheath that envelops nerve fibers. Myelin ensures efficient transmission of nerve impulses, underpinning neurological function. Furthermore, Vitamin B12 plays a key role in heme synthesis, a vital component of hemoglobin within red blood cells. Hemoglobin's function in oxygen transport makes it central to canine vitality.



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