Canine LN antibody and antigen (recombinant protein)

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Diagnostic anti-Canine LN antibodies pairs and antigen for animal health (animal Dog/Canine muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Size： 1mg | 10mg | 100mg

Product Description

Reference

Validation Data

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Target/Biomarker Information

The Canine Lymph Node (cLN) stands as an unsung hero in the canine body, hidden from plain view but orchestrating complex immune responses that safeguard a dog's health. Positioned strategically in various anatomical regions, the cLN serves as a sentinel, tirelessly monitoring the body's interstitial fluid, capturing antigens, and coordinating immune defenses.

Structurally, the cLN is an encapsulated organ, encapsulated by a fibrous tissue known as the capsule. This capsule houses a labyrinth of lymphatic sinuses and nodules where immune cells reside and interact. Within these microenvironments, immune cells are stationed, primed to detect and respond to potential threats. Among these immune cells, lymphocytes, the primary players of adaptive immunity, abound. T cells and B cells, distinct lymphocyte subsets, collaborate to recognize and target specific antigens, while macrophages act as the body's professional scavengers, clearing cellular debris and engulfing foreign invaders.

When antigens enter the lymphatic fluid, either through infection or other means, a series of events unfolds within the cLN. Antigen-presenting cells, including dendritic cells, encounter these antigens and capture them. They then migrate to the cLN, where they present the antigens to T cells. This presentation serves as a call to arms, activating T cells that recognize the specific antigen. B cells within the cLN also play a crucial role by producing antibodies that can neutralize invaders.

The cLN, in essence, functions as a training ground for immune cells. It is where naïve lymphocytes are exposed to antigens, learn to differentiate self from non-self, and develop memory responses. This training is critical for the dog's ability to mount swift and specific immune defenses upon subsequent encounters with the same antigens.

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