Canine PTH antibody and antigen (recombinant protein)

Diagnostic anti-Canine PTH antibodies pairs and antigen for animal health (animal Dog/Canine Hyperparathyroidism) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-PTH-Ag01Canine PTH$3090.00
GMP-CAN-PTH-Ab01Anti-Canine PTH mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-PTH-Ab02Anti-Canine PTH mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-PTH-Ab03Anti-Canine PTH human monoclonal antibody (mAb)$3090.00
GMP-CAN-PTH-Ab04Anti-Canine PTH human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-PTH-Ag01
Product NameCanine PTH
Target/BiomarkerCanine PTH
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine PTH antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PTH level test of animal Dog/Canine with Hyperparathyroidism.
TagHis
Reconized/Reactive SpecicsCanine PTH
Product descriptionRecombinant Canine PTH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-PTH-Ab01,GMP-CAN-PTH-Ab02
Target/BiomarkerCanine PTH
Product NameAnti-Canine PTH mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine PTH antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine PTH antibodies in Canine PTH level test of animal Dog/Canine with Hyperparathyroidism.
Product descriptionAnti-Canine PTH mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine PTH antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-PTH-Ab03,GMP-CAN-PTH-Ab04
Target/BiomarkerCanine PTH
Product NameAnti-Canine PTH human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine PTH antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine PTH antibodies in Canine PTH level test of animal Dog/Canine with Hyperparathyroidism.
Product descriptionAnti-Canine PTH mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine Parathyroid Hormone (cPTH) is a master regulator of calcium and phosphate homeostasis in dogs, a hormone that orchestrates a delicate symphony within the body to ensure the vital functions of these minerals. Structurally, cPTH is a single-chain polypeptide hormone composed of 84 amino acids. Its genesis primarily occurs within the parathyroid glands, small, pea-sized structures located near the thyroid gland.

    The fundamental role of cPTH revolves around maintaining ionized calcium levels within a narrow physiological range. When blood calcium levels dip below the optimal range, the parathyroid glands are primed to take action. These glands harbor specialized calcium-sensing receptors, which, upon detecting low calcium, trigger the release of cPTH into the bloodstream.

    Once released, cPTH embarks on its mission to restore calcium balance by acting on multiple target organs. Its primary target is bone, where it exerts its influence by stimulating osteoclasts—cells responsible for bone resorption. This process releases calcium stored within the bone matrix into the bloodstream. Simultaneously, cPTH influences the kidneys, encouraging the reabsorption of calcium from the urine, effectively reducing calcium loss.

    However, cPTH's involvement doesn't end there. It also plays a pivotal role in the gut, indirectly regulating calcium absorption from dietary sources. It achieves this by prompting the production of calcitriol, the active form of vitamin D, which, in turn, enhances the uptake of dietary calcium in the intestines.



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