Canine TPO antibody and antigen (recombinant protein)

Diagnostic anti-Canine TPO antibodies pairs and antigen for animal health (animal Dog/Canine Hashimoto's disease or Graves' disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-TPO-Ag01Canine TPO$3090.00
GMP-CAN-TPO-Ab01Anti-Canine TPO mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-TPO-Ab02Anti-Canine TPO mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-TPO-Ab03Anti-Canine TPO human monoclonal antibody (mAb)$3090.00
GMP-CAN-TPO-Ab04Anti-Canine TPO human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-TPO-Ag01
Product NameCanine TPO
Target/BiomarkerCanine TPO
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine TPO antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in TPO level test of animal Dog/Canine with Hashimoto's disease or Graves' disease.
TagHis
Reconized/Reactive SpecicsCanine TPO
Product descriptionRecombinant Canine TPO protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-TPO-Ab01,GMP-CAN-TPO-Ab02
Target/BiomarkerCanine TPO
Product NameAnti-Canine TPO mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine TPO antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine TPO antibodies in Canine TPO level test of animal Dog/Canine with Hashimoto's disease or Graves' disease.
Product descriptionAnti-Canine TPO mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine TPO antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-TPO-Ab03,GMP-CAN-TPO-Ab04
Target/BiomarkerCanine TPO
Product NameAnti-Canine TPO human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine TPO antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine TPO antibodies in Canine TPO level test of animal Dog/Canine with Hashimoto's disease or Graves' disease.
Product descriptionAnti-Canine TPO mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Thyroid Peroxidase (TPO) in dogs (canines) represents a linchpin of thyroid hormone production and, consequently, a cornerstone of metabolic regulation and overall health. As an enzyme localized primarily within the thyroid gland, TPO takes center stage in the intricate process of thyroid hormone synthesis.

    TPO's principal role hinges on its enzymatic activity, which catalyzes the iodination of tyrosine residues on thyroglobulin. Thyroglobulin is a substantial glycoprotein synthesized by thyroid follicular cells, serving as the reservoir for thyroid hormones. The iodination process facilitated by TPO is a fundamental step in thyroid hormone formation, converting thyroglobulin into the bioactive hormones thyroxine (T4) and triiodothyronine (T3). These hormones wield commanding influence over metabolic processes, energy expenditure, growth, and various physiological systems in dogs.

    The mechanism by which TPO operates is intricately tied to iodine utilization. Iodine, an essential trace element acquired through dietary sources, is actively transported into thyroid follicular cells, where it becomes the substrate for TPO. TPO channels iodine atoms onto specific tyrosine residues on thyroglobulin, creating mono- and diiodotyrosines. Subsequent coupling reactions between these iodinated tyrosine residues give rise to the formation of T4 and T3. This intricate sequence of enzymatic events, orchestrated by TPO, is the epicenter of thyroid hormone synthesis in dogs.



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