Canine TPO antibody and antigen (recombinant protein)

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Product information

Size： 1mg | 10mg | 100mg

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-CAN-TPO-Ag01	Recombinant Canine TPO protein	3090
GMP-CAN-TPO-Ab01	Anti-Canine TPO mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-TPO-Ab02	Anti-Canine TPO mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-TPO-Ab03	Anti-Canine TPO mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-TPO-Ab04	Anti-Canine TPO mouse monoclonal antibody (mAb)	1953	20%	1562.4

Shipping Costs: $360–$760
Antibodies: $360 Antigens: $760 (Elevated cost due to antigen heterogeneity, post-translational modifications, structural complexity, and specialized handling.)

Product Description

Cat No. of Products	GMP-CAN-TPO-Ag01
Product Name	Recombinant Canine TPO protein
Target/Biomarker	Canine Thyroid peroxidase (TPO)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Thyroid peroxidase antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in TPO level test of animal Dog/Canine with Hashimoto's disease or Graves' disease.
Tag	His
Products description	Recombinant Canine TPO protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-TPO-Ab01, GMP-CAN-TPO-Ab02, GMP-CAN-TPO-Ab03, GMP-CAN-TPO-Ab04
Product Name	Anti-Canine TPO mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Thyroid peroxidase (TPO)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Anti-Canine Thyroid peroxidase antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in TPO level test of animal Dog/Canine with Hashimoto's disease or Graves' disease.
Tag	mFc
Products description	Anti-Canine TPO mouse monoclonal antibody (mAb) was expressed in CHO - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Thyroid Peroxidase (TPO) in dogs (canines) represents a linchpin of thyroid hormone production and, consequently, a cornerstone of metabolic regulation and overall health. As an enzyme localized primarily within the thyroid gland, TPO takes center stage in the intricate process of thyroid hormone synthesis. TPO's principal role hinges on its enzymatic activity, which catalyzes the iodination of tyrosine residues on thyroglobulin. Thyroglobulin is a substantial glycoprotein synthesized by thyroid follicular cells, serving as the reservoir for thyroid hormones. The iodination process facilitated by TPO is a fundamental step in thyroid hormone formation, converting thyroglobulin into the bioactive hormones thyroxine (T4) and triiodothyronine (T3). These hormones wield commanding influence over metabolic processes, energy expenditure, growth, and various physiological systems in dogs. The mechanism by which TPO operates is intricately tied to iodine utilization. Iodine, an essential trace element acquired through dietary sources, is actively transported into thyroid follicular cells, where it becomes the substrate for TPO. TPO channels iodine atoms onto specific tyrosine residues on thyroglobulin, creating mono- and diiodotyrosines. Subsequent coupling reactions between these iodinated tyrosine residues give rise to the formation of T4 and T3. This intricate sequence of enzymatic events, orchestrated by TPO, is the epicenter of thyroid hormone synthesis in dogs.

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