Canine TSH antibody and antigen (recombinant protein)

Diagnostic anti-Canine TSH antibodies pairs and antigen for animal health (animal Dog/Canine Hypothyroidism, hyperthyroidism) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-TSH-Ag01Canine TSH$3090.00
GMP-CAN-TSH-Ab01Anti-Canine TSH mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-TSH-Ab02Anti-Canine TSH mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-TSH-Ab03Anti-Canine TSH human monoclonal antibody (mAb)$3090.00
GMP-CAN-TSH-Ab04Anti-Canine TSH human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-TSH-Ag01
Product NameCanine TSH
Target/BiomarkerCanine TSH
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine TSH antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in TSH level test of animal Dog/Canine with Hypothyroidism, hyperthyroidism.
TagHis
Reconized/Reactive SpecicsCanine TSH
Product descriptionRecombinant Canine TSH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-TSH-Ab01,GMP-CAN-TSH-Ab02
Target/BiomarkerCanine TSH
Product NameAnti-Canine TSH mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine TSH antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine TSH antibodies in Canine TSH level test of animal Dog/Canine with Hypothyroidism, hyperthyroidism.
Product descriptionAnti-Canine TSH mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine TSH antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-TSH-Ab03,GMP-CAN-TSH-Ab04
Target/BiomarkerCanine TSH
Product NameAnti-Canine TSH human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine TSH antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine TSH antibodies in Canine TSH level test of animal Dog/Canine with Hypothyroidism, hyperthyroidism.
Product descriptionAnti-Canine TSH mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Thyroid-Stimulating Hormone (TSH) is a master regulator of thyroid gland activity in dogs, exerting a profound influence on their metabolic well-being. This glycoprotein hormone is at the core of the intricate network known as the hypothalamic-pituitary-thyroid (HPT) axis. Produced and secreted by the anterior pituitary gland in response to fluctuations in thyroid hormone levels, TSH plays a pivotal role in maintaining thyroid homeostasis.

    Structurally, TSH is a heterodimeric glycoprotein consisting of alpha and beta subunits. Its production is triggered by a sensor system within the hypothalamus-pituitary complex, specifically the hypothalamus's release of thyrotropin-releasing hormone (TRH) and the subsequent secretion of thyroid-releasing hormone (TRH). Low levels of thyroid hormones (triiodothyronine or T3 and thyroxine or T4) in the bloodstream serve as the primary stimulants for TSH release.

    Once released, TSH travels via the bloodstream to the thyroid gland, where it binds to specific receptors on the thyroid follicular cells. This binding event triggers a cascade of intracellular processes that culminate in increased thyroid hormone production and secretion. TSH acts as the conductor of the thyroid orchestra, orchestrating the synthesis and release of T3 and T4 to meet the metabolic demands of the dog's body.

    The importance of TSH in canine physiology cannot be overstated. It ensures that the metabolic rate is finely tuned to meet the body's energy needs. During periods of increased metabolic demands, such as growth, pregnancy, or exposure to cold temperatures, TSH rises to stimulate greater thyroid hormone production, thereby ramping up the metabolic furnace. Conversely, when metabolic needs diminish, TSH levels decrease, conserving energy resources.



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