Canine Tau antibody and antigen (recombinant protein)

Diagnostic anti-Canine Tau antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-Tau-Ag01Canine Tau$3090.00
GMP-CAN-Tau-Ab01Anti-Canine Tau mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-Tau-Ab02Anti-Canine Tau mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-Tau-Ab03Anti-Canine Tau human monoclonal antibody (mAb)$3090.00
GMP-CAN-Tau-Ab04Anti-Canine Tau human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-Tau-Ag01
Product NameCanine Tau
Target/BiomarkerCanine Tau
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine Tau antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Tau level test of animal Dog/Canine with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsCanine Tau
Product descriptionRecombinant Canine Tau protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-Tau-Ab01,GMP-CAN-Tau-Ab02
Target/BiomarkerCanine Tau
Product NameAnti-Canine Tau mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine Tau antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Tau antibodies in Canine Tau level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine Tau mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Tau antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-Tau-Ab03,GMP-CAN-Tau-Ab04
Target/BiomarkerCanine Tau
Product NameAnti-Canine Tau human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine Tau antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Tau antibodies in Canine Tau level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine Tau mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine Tau represents a linchpin in the intricate tapestry of canine neurobiology. This protein, primarily localized within the central nervous system (CNS) of dogs, stands as a guardian of neuronal structural integrity and function. Its structural and functional homology to tau proteins in other species, including humans, underscores its critical role in maintaining proper neurological health.

    Structurally, Canine Tau is a member of the tau protein family, sharing commonalities with its counterparts in diverse organisms. Its primary function is to bind to microtubules within neurons, promoting their assembly and stability. Microtubules are essential cellular structures that facilitate axonal transport, synaptic plasticity, and overall neuronal communication.

    However, the equilibrium of tau proteins like Canine Tau can be disrupted in the context of neurodegenerative conditions observed in dogs. Tau proteins may undergo post-translational modifications, including hyperphosphorylation. These modifications lead to tau proteins adopting abnormal conformations, rendering them susceptible to aggregation. The aggregation of tau proteins culminates in the formation of neurofibrillary tangles within neurons. These tangles impede axonal transport, impair synaptic function, and eventually result in neuronal dysfunction and degeneration.

    The presence of elevated levels of Canine Tau in specific contexts can serve as an indicator of these pathological processes, signaling the potential emergence of cognitive and neurological deficits in affected dogs.



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    GDU

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