Canine α-defensin 5 antibody and antigen (recombinant protein)

Diagnostic anti-Canine α-defensin 5 antibodies pairs and antigen for animal health (animal Dog/Canine Prosthetic joint infection (PJI)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-a-defensin-5-Ag01Canine α-defensin 5$3090.00
GMP-CAN-a-defensin-5-Ab01Anti-Canine α-defensin 5 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-a-defensin-5-Ab02Anti-Canine α-defensin 5 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-a-defensin-5-Ab03Anti-Canine α-defensin 5 human monoclonal antibody (mAb)$3090.00
GMP-CAN-a-defensin-5-Ab04Anti-Canine α-defensin 5 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-a-defensin-5-Ag01
Product NameCanine α-defensin 5
Target/BiomarkerCanine α-defensin 5
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine α-defensin 5 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in α-defensin 5 level test of animal Dog/Canine with Prosthetic joint infection (PJI).
TagHis
Reconized/Reactive SpecicsCanine α-defensin 5
Product descriptionRecombinant Canine α-defensin 5 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-a-defensin-5-Ab01,GMP-CAN-a-defensin-5-Ab02
Target/BiomarkerCanine α-defensin 5
Product NameAnti-Canine α-defensin 5 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine α-defensin 5 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine α-defensin 5 antibodies in Canine α-defensin 5 level test of animal Dog/Canine with Prosthetic joint infection (PJI).
Product descriptionAnti-Canine α-defensin 5 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine α-defensin 5 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-a-defensin-5-Ab03,GMP-CAN-a-defensin-5-Ab04
Target/BiomarkerCanine α-defensin 5
Product NameAnti-Canine α-defensin 5 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine α-defensin 5 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine α-defensin 5 antibodies in Canine α-defensin 5 level test of animal Dog/Canine with Prosthetic joint infection (PJI).
Product descriptionAnti-Canine α-defensin 5 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    α-defensin 5, or Def5, is a remarkable antimicrobial peptide found in the canine digestive system, specifically in the small intestine. It is a member of the α-defensin family, which comprises small, cationic peptides known for their potent antimicrobial properties. These peptides are pivotal components of the innate immune system, contributing significantly to the host's defense against invading pathogens.

    The synthesis and secretion of α-defensin 5 primarily occur within Paneth cells, specialized secretory cells located in the crypts of Lieberkühn in the small intestine. These cells are strategically positioned to defend the intestinal epithelium from harmful microorganisms. α-defensin 5 is part of this frontline defense mechanism, actively engaging and neutralizing a wide range of bacteria, viruses, and fungi that may enter the digestive tract.

    Structurally, α-defensin 5 possesses a unique arrangement of cysteine residues that form disulfide bonds. These bonds not only provide structural stability but also enhance its antimicrobial activity. This biomarker exhibits a remarkable ability to disrupt microbial cell membranes, leading to their lysis and subsequent elimination from the gastrointestinal tract.



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