Canine sTREM2 antibody and antigen (recombinant protein)

Diagnostic anti-Canine sTREM2 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-sTREM2-Ag01Canine sTREM2$3090.00
GMP-CAN-sTREM2-Ab01Anti-Canine sTREM2 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-sTREM2-Ab02Anti-Canine sTREM2 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-sTREM2-Ab03Anti-Canine sTREM2 human monoclonal antibody (mAb)$3090.00
GMP-CAN-sTREM2-Ab04Anti-Canine sTREM2 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-sTREM2-Ag01
Product NameCanine sTREM2
Target/BiomarkerCanine sTREM2
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine sTREM2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in sTREM2 level test of animal Dog/Canine with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsCanine sTREM2
Product descriptionRecombinant Canine sTREM2 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-sTREM2-Ab01,GMP-CAN-sTREM2-Ab02
Target/BiomarkerCanine sTREM2
Product NameAnti-Canine sTREM2 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine sTREM2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine sTREM2 antibodies in Canine sTREM2 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine sTREM2 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine sTREM2 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-sTREM2-Ab03,GMP-CAN-sTREM2-Ab04
Target/BiomarkerCanine sTREM2
Product NameAnti-Canine sTREM2 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine sTREM2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine sTREM2 antibodies in Canine sTREM2 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine sTREM2 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Soluble Triggering Receptor Expressed on Myeloid Cells-2 (sTREM2) emerges as a fascinating component of the canine immune and central nervous systems. In its soluble form, sTREM2 represents a distinct functional entity compared to its membrane-bound counterpart, TREM2. sTREM2 is generated through proteolytic cleavage of the membrane-bound receptor and can be found in the cerebrospinal fluid and bloodstream of dogs.

    Structurally, sTREM2 shares homology with its membrane-bound counterpart but lacks the transmembrane domain. Instead, it retains the extracellular domain responsible for interactions with various ligands and immune cells. This unique structure allows sTREM2 to exert its functions within the canine body.

    Functionally, sTREM2 is a key player in the modulation of immune responses within the central nervous system of dogs. Its presence is particularly notable in microglia, specialized immune cells resident in the brain. sTREM2 acts as a signaling molecule, influencing the behavior of microglia and other immune cells, especially in the context of neuroinflammation.

    Importantly, sTREM2's role goes beyond immune modulation. Research suggests that sTREM2 is involved in the phagocytic clearance of cellular debris and potentially contributes to the resolution of inflammation in the canine brain. This multifaceted functionality underscores the importance of sTREM2 in maintaining the balance between immune responses and neurological health in dogs.



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