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Equine Aβ40 antibody and antigen (recombinant protein)
Diagnostic anti-Equine Aβ40 antibodies pairs and antigen for animal health (animal Equine/Horse Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
| Catalog No. | Description | US $ Price (per mg) |
|---|---|---|
| GMP-EQU-AB40-Ag01 | Equine Aβ40 | $3090.00 |
| GMP-EQU-AB40-Ab01 | Anti-Equine Aβ40 mouse monoclonal antibody (mAb) | $3090.00 |
| GMP-EQU-AB40-Ab02 | Anti-Equine Aβ40 mouse monoclonal antibody (mAb) | $3090.00 |
| GMP-EQU-AB40-Ab03 | Anti-Equine Aβ40 human monoclonal antibody (mAb) | $3090.00 |
| GMP-EQU-AB40-Ab04 | Anti-Equine Aβ40 human monoclonal antibody (mAb) | $3090.00 |
Size： 1mg | 10mg | 100mg
Product Description
| Cat No. | GMP-EQU-AB40-Ag01 |
| Product Name | Equine Aβ40 |
| Target/Biomarker | Equine Aβ40 |
| Expression platform | E.coli |
| Isotypes | Recombinant Antigen |
| Bioactivity validation | Anti-Equine Aβ40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ40 level test of animal Equine/Horse with Alzheimer Disease(AD). |
| Tag | His | Reconized/Reactive Specics | Equine Aβ40 |
| Product description | Recombinant Equine Aβ40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
| Cat No. | GMP-EQU-AB40-Ab01,GMP-EQU-AB40-Ab02 |
| Target/Biomarker | Equine Aβ40 |
| Product Name | Anti-Equine Aβ40 mouse monoclonal antibody (mAb) |
| Expression platform | CHO |
| Isotypes | Mouse IgG |
| Bioactivity validation | Recombinant Equine Aβ40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine Aβ40 antibodies in Equine Aβ40 level test of animal Equine/Horse with Alzheimer Disease(AD). |
| Product description | Anti-Equine Aβ40 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine Aβ40 antibodies. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
| Cat No. | GMP-EQU-AB40-Ab03,GMP-EQU-AB40-Ab04 |
| Target/Biomarker | Equine Aβ40 |
| Product Name | Anti-Equine Aβ40 human monoclonal antibody (mAb) |
| Expression platform | CHO |
| Isotypes | Human lgG1 |
| Bioactivity validation | Recombinant Equine Aβ40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine Aβ40 antibodies in Equine Aβ40 level test of animal Equine/Horse with Alzheimer Disease(AD). |
| Product description | Anti-Equine Aβ40 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
Click to get more Data / Case study about the product.
Target/Biomarker Information
Equine Amyloid-beta 40 (Aβ40) is a remarkable molecule in equine neuroscience, occupying a central role in our understanding of neurodegenerative conditions affecting our noble equine companions. Comprising 40 amino acids, Aβ40 is a fragment of the amyloid precursor protein (APP) and stands as a critical component in the formation of amyloid plaques within the equine brain. These plaques, primarily composed of Aβ40, have come to symbolize cognitive decline in horses, most notably in cases of equine cognitive dysfunction syndrome (ECDS).
The genesis of Aβ40 involves proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In horses afflicted by ECDS, a perturbation in Aβ40 metabolism and clearance results in its aggregation, leading to the accumulation of amyloid plaques. These plaques disrupt normal neuronal function, contributing substantially to the cognitive deficits seen in affected horses.
The ramifications of Aβ40 aggregation extend further, encompassing a cascade of deleterious effects. These include neuroinflammation, oxidative stress, and synaptic dysfunction, all of which collectively contribute to the progressive cognitive deficits witnessed in horses suffering from ECDS.
About GDU
GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.
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